Mucinous tubular and spindle cell carcinoma of kidney: A distinct morphologic entity of renal cell carcinoma

Harin Cheong, Jae Ro, Federico A. Monzon, Alberto Ayala, Steven Shen

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare morphologic variant of renal cell carcinoma (RCC) characterized by an epithelial-tubular proliferation admixed with spindle cell areas and a myxoid or mucinous stroma. It was initially referred as an unusual renal carcinoma with prominent spindle cell change, RCC with loop of Henle differentiation, low-grade myxoid tumor, and low grade collecting duct carcinoma.1-6 In 2004, it has been recognized as a distinct entity of RCC in the 2004 World Health Organization tumor classification.7,8 Since then, several dozen of MTSCCs have been reported with additional complementary morphologic features, immunohistochemical profiles, and cytogenetic changes that have further clarified its clinicopathologic features.9-14 It was initially thought to be a "low-grade" renal cell tumor because of its bland nuclear features and indolent behavior. However, it has became clear that MTSCC has a histological spectrum ranging from low to high grade that includes, rarely, sarcomatoid differentiation. In addition to nodal metastasis, distant metastasis and death of patients have been described.15-17 Herein, we present a case of MTSCC and summarize the current knowledge regarding histological and immunohistochemical features, differential diagnosis, and prognostic factors.

Original languageEnglish (US)
Pages (from-to)7-10
Number of pages4
JournalPathology Case Reviews
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Mucinous tubular spindle cell carcinoma
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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