mTOR Signaling in Parkinson’s Disease

Ai ping Lan, Jun Chen, Yuliang Zhao, Zhifang Chai, Yi Hu

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mTOR) emerges as a novel therapeutic target for Parkinson’s disease (PD). A growing body of research indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal cell death. Nevertheless, molecular mechanisms underlying mTOR-mediated effects in PD have not been fully understood yet. Here, we review recent progress in characterizing the association of mTOR signaling with PD risk factors and further discuss the potential roles of mTOR in PD.

Original languageEnglish (US)
JournalNeuroMolecular Medicine
Volume19
Issue number1
DOIs
StatePublished - Mar 1 2017

Keywords

  • Apoptosis
  • Oxidative stress
  • Parkinson’s disease
  • mTOR
  • α-Synuclein

ASJC Scopus subject areas

  • Molecular Medicine
  • Neurology
  • Cellular and Molecular Neuroscience

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