m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

Huan Xu, Yulia Dzhashiashvili, Ankeeta Shah, Rejani B. Kunjamma, Yi lan Weng, Benayahu Elbaz, Qili Fei, Joshua S. Jones, Yang I. Li, Xiaoxi Zhuang, Guo li Ming, Chuan He, Brian Popko

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Xu et al. show that oligodendrocyte development is associated with dynamic changes in posttranscriptional mRNA methylation. Moreover, they demonstrate that the m6A epigenetic RNA mark has considerable impact on the myelinating cell's transcriptome and is essential for normal CNS myelination.

Original languageEnglish (US)
Pages (from-to)293-309.e5
Issue number2
StatePublished - Jan 22 2020


  • Mettl14
  • NF155
  • RNA epigenetic regulation
  • alternative splicing
  • m(6)A
  • mRNA methylation
  • myelin
  • oligodendrocyte development
  • oligodendrocyte precursor cells
  • oligodendrocytes
  • Oligodendrocyte Precursor Cells/physiology
  • Cell Count
  • Male
  • Cell Adhesion Molecules/metabolism
  • Cell Differentiation/physiology
  • Female
  • Methyltransferases/genetics
  • Nerve Growth Factors/metabolism
  • Cells, Cultured
  • Mice, Transgenic
  • Myelin Sheath/physiology
  • RNA, Messenger/metabolism
  • Cell Lineage
  • Adenosine/analogs & derivatives
  • Animals
  • Mice
  • Methylation
  • Oligodendroglia/cytology

ASJC Scopus subject areas

  • Neuroscience(all)


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