m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

Huan Xu; Yulia Dzhashiashvili; Ankeeta Shah; Rejani B. Kunjamma; Yi lan Weng; Benayahu Elbaz; Qili Fei; Joshua S. Jones; Yang I. Li; Xiaoxi Zhuang; Guo li Ming; Chuan He; Brian Popko

doi:10.1016/j.neuron.2019.12.013

m⁶A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

Huan Xu, Yulia Dzhashiashvili, Ankeeta Shah, Rejani B. Kunjamma, Yi lan Weng, Benayahu Elbaz, Qili Fei, Joshua S. Jones, Yang I. Li, Xiaoxi Zhuang, Guo li Ming, Chuan He, Brian Popko

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Xu et al. show that oligodendrocyte development is associated with dynamic changes in posttranscriptional mRNA methylation. Moreover, they demonstrate that the m⁶A epigenetic RNA mark has considerable impact on the myelinating cell's transcriptome and is essential for normal CNS myelination.

Original language	English (US)
Pages (from-to)	293-309.e5
Journal	Neuron
Volume	105
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2019.12.013
State	Published - Jan 22 2020

Keywords

Mettl14
NF155
RNA epigenetic regulation
alternative splicing
m(6)A
mRNA methylation
myelin
oligodendrocyte development
oligodendrocyte precursor cells
oligodendrocytes
Oligodendrocyte Precursor Cells/physiology
Cell Count
Male
Cell Adhesion Molecules/metabolism
Cell Differentiation/physiology
Female
Methyltransferases/genetics
Nerve Growth Factors/metabolism
Cells, Cultured
Mice, Transgenic
Myelin Sheath/physiology
RNA, Messenger/metabolism
Cell Lineage
Adenosine/analogs & derivatives
Animals
Mice
Methylation
Oligodendroglia/cytology

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/j.neuron.2019.12.013

Cite this

@article{80e2e85ebaf542ef80eccf9108fb6793,

title = "m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination",

abstract = "Xu et al. show that oligodendrocyte development is associated with dynamic changes in posttranscriptional mRNA methylation. Moreover, they demonstrate that the m6A epigenetic RNA mark has considerable impact on the myelinating cell's transcriptome and is essential for normal CNS myelination.",

keywords = "Mettl14, NF155, RNA epigenetic regulation, alternative splicing, m(6)A, mRNA methylation, myelin, oligodendrocyte development, oligodendrocyte precursor cells, oligodendrocytes, Oligodendrocyte Precursor Cells/physiology, Cell Count, Male, Cell Adhesion Molecules/metabolism, Cell Differentiation/physiology, Female, Methyltransferases/genetics, Nerve Growth Factors/metabolism, Cells, Cultured, Mice, Transgenic, Myelin Sheath/physiology, RNA, Messenger/metabolism, Cell Lineage, Adenosine/analogs & derivatives, Animals, Mice, Methylation, Oligodendroglia/cytology",

author = "Huan Xu and Yulia Dzhashiashvili and Ankeeta Shah and Kunjamma, {Rejani B.} and Weng, {Yi lan} and Benayahu Elbaz and Qili Fei and Jones, {Joshua S.} and Li, {Yang I.} and Xiaoxi Zhuang and Ming, {Guo li} and Chuan He and Brian Popko",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2020",

month = jan,

day = "22",

doi = "10.1016/j.neuron.2019.12.013",

language = "English (US)",

volume = "105",

pages = "293--309.e5",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "2",

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T1 - m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

AU - Xu, Huan

AU - Dzhashiashvili, Yulia

AU - Shah, Ankeeta

AU - Kunjamma, Rejani B.

AU - Weng, Yi lan

AU - Elbaz, Benayahu

AU - Fei, Qili

AU - Jones, Joshua S.

AU - Li, Yang I.

AU - Zhuang, Xiaoxi

AU - Ming, Guo li

AU - He, Chuan

AU - Popko, Brian

PY - 2020/1/22

Y1 - 2020/1/22

N2 - Xu et al. show that oligodendrocyte development is associated with dynamic changes in posttranscriptional mRNA methylation. Moreover, they demonstrate that the m6A epigenetic RNA mark has considerable impact on the myelinating cell's transcriptome and is essential for normal CNS myelination.

AB - Xu et al. show that oligodendrocyte development is associated with dynamic changes in posttranscriptional mRNA methylation. Moreover, they demonstrate that the m6A epigenetic RNA mark has considerable impact on the myelinating cell's transcriptome and is essential for normal CNS myelination.

KW - Mettl14

KW - NF155

KW - RNA epigenetic regulation

KW - alternative splicing

KW - m(6)A

KW - mRNA methylation

KW - myelin

KW - oligodendrocyte development

KW - oligodendrocyte precursor cells

KW - oligodendrocytes

KW - Oligodendrocyte Precursor Cells/physiology

KW - Cell Count

KW - Male

KW - Cell Adhesion Molecules/metabolism

KW - Cell Differentiation/physiology

KW - Female

KW - Methyltransferases/genetics

KW - Nerve Growth Factors/metabolism

KW - Cells, Cultured

KW - Mice, Transgenic

KW - Myelin Sheath/physiology

KW - RNA, Messenger/metabolism

KW - Cell Lineage

KW - Adenosine/analogs & derivatives

KW - Animals

KW - Mice

KW - Methylation

KW - Oligodendroglia/cytology

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