MRI quantitative myocardial perfusion with compartmental analysis: A rest and stress study

Jean Paul Vallée, H. Dirk Sostman, James R. MacFall, Ted Wheeler, Larry W. Hedlund, Charles E. Spritzer, R. Edward Coleman

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


K1 [first-order transfer constant from arterial plasma to myocardium for Gd-DTPA) and Vd (distribution volume of Gd-DTPA in myocardium) were measured in vivo in a canine model (n = 5) using MRI-derived myocardial perfusion curves and a compartmental model. Perfusion curves were obtained after a bolus injection of Gd-DTPA (0.04 mM/kg) with an inversion-prepared fast gradient echo sequence. Myocardium and blood signal intensity were converted to a concentration of Gd-DTPA, according to a model appropriate for short (< 1 s) interimage intervals characteristic of cardiac-triggered acquisitions. Before dipyridamole-induced stress, K1 and Vd, obtained from the fit of the MRI-derived perfusion curves, were 6.2± 1.4 (mHz) and 17.5 ± 4.2%, respectively. After dipyridamole infusion, a K1 increase of a factor of 2.82 ± 0.72 was measured (P = 0.003). No change was observed in Vd (P = 0.98). These results suggest that the K1 increase after dipyridamole reflects a flow-related effect that can be useful to quantify the MRI- derived perfusion curves.

Original languageEnglish (US)
Pages (from-to)981-989
Number of pages9
JournalMagnetic Resonance in Medicine
Issue number6
StatePublished - Dec 1997


  • Dipyridamole
  • Gadolinium
  • Heart
  • T

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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