MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas

H. D. Sostman, D. M. Prescott, M. W. Dewhirst, R. K. Dodge, D. E. Thrall, R. L. Page, J. A. Tucker, J. M. Harrelson, G. Reece, K. A. Leopold, J. R. Oleson, H. C. Charles

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

PURPOSE: To enable prediction of tumor response to a particular treatment. MATERIALS AND METHODS: The authors studied the value of hydrogen-1 T2 and phosphorus-31 magnetic resonance (MR) spectroscopic metabolic determinations as indicators of prognosis in 20 humans and 10 dogs with soft-tissue sarcomas. All patients underwent combined fractionated radiation therapy and hyperthermia. Surgical resection of the entire tumor in humans allowed comparison of pretherapy T2 and MR spectroscopic parameters with subsequent histologic findings. Long-term clinical follow-up (no surgical intervention) was available with the dogs and allowed comparison of pretherapy pH with the duration of local relapse-free survival. RESULTS: A relationship exists between pretherapy pH and T2 and ultimate tumor necrosis in humans and pretherapy pH and time elapsed until local failure in dogs. CONCLUSION: MR imaging and spectroscopy could be useful in the prognosis of patients with soft-tissue sarcomas before therapy is initiated.

Original languageEnglish (US)
Pages (from-to)269-275
Number of pages7
JournalRadiology
Volume190
Issue number1
DOIs
StatePublished - 1994

Keywords

  • Magnetic resonance (MR), phosphorus studies
  • Magnetic resonance (MR), spectroscopy
  • Soft tissues, neoplasms, 40.37

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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