MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas

H. Dirk Sostman; Deborah M. Prescott; Mark W. Dewhirst; Richard K. Dodge; Donald E. Thrall; Rod L. Page; J. Allan Tucker; John M. Harrelson; Gerry Reece; Kenneth A. Leopold; James R. Oleson; H. Cecil Charles

doi:10.1148/radiology.190.1.8259418

MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas

H. Dirk Sostman, Deborah M. Prescott, Mark W. Dewhirst, Richard K. Dodge, Donald E. Thrall, Rod L. Page, J. Allan Tucker, John M. Harrelson, Gerry Reece, Kenneth A. Leopold, James R. Oleson, H. Cecil Charles

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

PURPOSE: To enable prediction of tumor response to a particular treatment. MATERIALS AND METHODS: The authors studied the value of hydrogen-1 T2 and phosphorus-31 magnetic resonance (MR) spectroscopic metabolic determinations as indicators of prognosis in 20 humans and 10 dogs with soft-tissue sarcomas. All patients underwent combined fractionated radiation therapy and hyperthermia. Surgical resection of the entire tumor in humans allowed comparison of pretherapy T2 and MR spectroscopic parameters with subsequent histologic findings. Long-term clinical follow-up (no surgical intervention) was available with the dogs and allowed comparison of pretherapy pH with the duration of local relapse-free survival. RESULTS: A relationship exists between pretherapy pH and T2 and ultimate tumor necrosis in humans and pretherapy pH and time elapsed until local failure in dogs. CONCLUSION: MR imaging and spectroscopy could be useful in the prognosis of patients with soft-tissue sarcomas before therapy is initiated.

Original language	English (US)
Pages (from-to)	269-275
Number of pages	7
Journal	Radiology
Volume	190
Issue number	1
DOIs	https://doi.org/10.1148/radiology.190.1.8259418
State	Published - Jan 1994

Keywords

Magnetic resonance (MR), phosphorus studies
Magnetic resonance (MR), spectroscopy
Soft tissues, neoplasms, 40.37

ASJC Scopus subject areas

Radiological and Ultrasound Technology

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10.1148/radiology.190.1.8259418

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@article{5bb96758f9b0486ea4938311b7500d94,

title = "MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas",

abstract = "PURPOSE: To enable prediction of tumor response to a particular treatment. MATERIALS AND METHODS: The authors studied the value of hydrogen-1 T2 and phosphorus-31 magnetic resonance (MR) spectroscopic metabolic determinations as indicators of prognosis in 20 humans and 10 dogs with soft-tissue sarcomas. All patients underwent combined fractionated radiation therapy and hyperthermia. Surgical resection of the entire tumor in humans allowed comparison of pretherapy T2 and MR spectroscopic parameters with subsequent histologic findings. Long-term clinical follow-up (no surgical intervention) was available with the dogs and allowed comparison of pretherapy pH with the duration of local relapse-free survival. RESULTS: A relationship exists between pretherapy pH and T2 and ultimate tumor necrosis in humans and pretherapy pH and time elapsed until local failure in dogs. CONCLUSION: MR imaging and spectroscopy could be useful in the prognosis of patients with soft-tissue sarcomas before therapy is initiated.",

keywords = "Magnetic resonance (MR), phosphorus studies, Magnetic resonance (MR), spectroscopy, Soft tissues, neoplasms, 40.37",

author = "Sostman, {H. Dirk} and Prescott, {Deborah M.} and Dewhirst, {Mark W.} and Dodge, {Richard K.} and Thrall, {Donald E.} and Page, {Rod L.} and Tucker, {J. Allan} and Harrelson, {John M.} and Gerry Reece and Leopold, {Kenneth A.} and Oleson, {James R.} and Charles, {H. Cecil}",

year = "1994",

month = jan,

doi = "10.1148/radiology.190.1.8259418",

language = "English (US)",

volume = "190",

pages = "269--275",

journal = "Radiology",

issn = "0033-8419",

publisher = "Radiological Society of North America Inc.",

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TY - JOUR

T1 - MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas

AU - Sostman, H. Dirk

AU - Prescott, Deborah M.

AU - Dewhirst, Mark W.

AU - Dodge, Richard K.

AU - Thrall, Donald E.

AU - Page, Rod L.

AU - Tucker, J. Allan

AU - Harrelson, John M.

AU - Reece, Gerry

AU - Leopold, Kenneth A.

AU - Oleson, James R.

AU - Charles, H. Cecil

PY - 1994/1

Y1 - 1994/1

N2 - PURPOSE: To enable prediction of tumor response to a particular treatment. MATERIALS AND METHODS: The authors studied the value of hydrogen-1 T2 and phosphorus-31 magnetic resonance (MR) spectroscopic metabolic determinations as indicators of prognosis in 20 humans and 10 dogs with soft-tissue sarcomas. All patients underwent combined fractionated radiation therapy and hyperthermia. Surgical resection of the entire tumor in humans allowed comparison of pretherapy T2 and MR spectroscopic parameters with subsequent histologic findings. Long-term clinical follow-up (no surgical intervention) was available with the dogs and allowed comparison of pretherapy pH with the duration of local relapse-free survival. RESULTS: A relationship exists between pretherapy pH and T2 and ultimate tumor necrosis in humans and pretherapy pH and time elapsed until local failure in dogs. CONCLUSION: MR imaging and spectroscopy could be useful in the prognosis of patients with soft-tissue sarcomas before therapy is initiated.

AB - PURPOSE: To enable prediction of tumor response to a particular treatment. MATERIALS AND METHODS: The authors studied the value of hydrogen-1 T2 and phosphorus-31 magnetic resonance (MR) spectroscopic metabolic determinations as indicators of prognosis in 20 humans and 10 dogs with soft-tissue sarcomas. All patients underwent combined fractionated radiation therapy and hyperthermia. Surgical resection of the entire tumor in humans allowed comparison of pretherapy T2 and MR spectroscopic parameters with subsequent histologic findings. Long-term clinical follow-up (no surgical intervention) was available with the dogs and allowed comparison of pretherapy pH with the duration of local relapse-free survival. RESULTS: A relationship exists between pretherapy pH and T2 and ultimate tumor necrosis in humans and pretherapy pH and time elapsed until local failure in dogs. CONCLUSION: MR imaging and spectroscopy could be useful in the prognosis of patients with soft-tissue sarcomas before therapy is initiated.

KW - Magnetic resonance (MR), phosphorus studies

KW - Magnetic resonance (MR), spectroscopy

KW - Soft tissues, neoplasms, 40.37

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SN - 0033-8419

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SP - 269

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JO - Radiology

JF - Radiology

IS - 1

ER -

MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas

Abstract

Keywords

ASJC Scopus subject areas

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