Moxalactam Plus Ticarcillin or Tobramycin for Treatment of Febrile Episodes in Neutropenic Cancer Patients

Victor Fainstein, Gerald P. Bodey, Ricardo Bolivar, Linda Elting, Kenneth B. Mccredie, Michael J. Keating

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Moxalactam disodium In combination with ticarcillin disodium or tobramycin sulfate was used to treat 445 episodes of suspected or confirmed infection In patients with cancer. The majority had leukemia and neutropenla. The rate of cures during the 231 confirmed infections was 65% for moxalactam and ticarcillin and 64% for moxalactam and tobramycin. Both regimens were comparable agalpst aerobic gram-negative and polymicrobial Infections. In gram-positive infections, the response rate for moxalactam and ticarcillin was 73% and for moxalactam and tobramycin, 53%. Only three of nine enterococcal Infections responded to treatment. Thirteen percent of all organisms recovered were resistant to moxalactam. Side effects occurred infrequently; the most important was coagulopathy due to moxalactam. Nephrotoxic effects occurred in six patients receiving moxalactam and tobramycin and in none of those receiving moxalactam and ticarcillin. In 39 patients, a superinfection was confirmed. Fourteen were fungal, three were due to enterococcus, and one due to Klebsiella species. Eleven of the 14 fungal episodes occurred in the moxalactamticarcillin group. Moxalactam with ticarcillin and moxalactam with tobramycin are equally active for the Initial treatment of presumed infection In patients with neutropenia.

Original languageEnglish (US)
Pages (from-to)1766-1770
Number of pages5
JournalArchives of Internal Medicine
Volume144
Issue number9
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Internal Medicine

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