Moving From the Background Toward the Spotlight: A Critical Review of Radiation Therapy for Locally Advanced Pancreas Cancer

Michael D. Chuong; Jonathan Ashman; Krishan Jethwa; Jordan Kharofa; Hyun Kim; Eugene Koay; Ethan Ludmir; Eric Miller; Bailey Nelson; Marsha Reyngold; Nina Sanford; Daniel Chang

doi:10.1016/j.ijrobp.2025.02.022

Moving From the Background Toward the Spotlight: A Critical Review of Radiation Therapy for Locally Advanced Pancreas Cancer

Michael D. Chuong, Jonathan Ashman, Krishan Jethwa, Jordan Kharofa, Hyun Kim, Eugene Koay, Ethan Ludmir, Eric Miller, Bailey Nelson, Marsha Reyngold, Nina Sanford, Daniel Chang

Research output: Contribution to journal › Review article › peer-review

Abstract

Radiation therapy (RT) for locally advanced pancreatic cancer (LAPC) continues to be controversial. Advances in both systemic therapy and RT techniques have changed the landscape of LAPC management in recent years. Clinical outcomes of ablative RT have been encouraging, and randomized clinical trials may clarify the role of RT for LAPC. We present a contemporary critical review of key aspects regarding optimal patient selection, radiation dose escalation techniques, novel radiosensitizers and radioprotectors, and treatment response assessment for LAPC.

Original language	English (US)
Pages (from-to)	294-312
Number of pages	19
Journal	International Journal of Radiation Oncology Biology Physics
Volume	122
Issue number	2
DOIs	https://doi.org/10.1016/j.ijrobp.2025.02.022
State	Accepted/In press - 2025

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/j.ijrobp.2025.02.022

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Chuong, M. D., Ashman, J., Jethwa, K., Kharofa, J., Kim, H., Koay, E., Ludmir, E., Miller, E., Nelson, B., Reyngold, M., Sanford, N., & Chang, D. (Accepted/In press). Moving From the Background Toward the Spotlight: A Critical Review of Radiation Therapy for Locally Advanced Pancreas Cancer. International Journal of Radiation Oncology Biology Physics, 122(2), 294-312. https://doi.org/10.1016/j.ijrobp.2025.02.022

Chuong, MD, Ashman, J, Jethwa, K, Kharofa, J, Kim, H, Koay, E, Ludmir, E, Miller, E, Nelson, B, Reyngold, M, Sanford, N & Chang, D 2025, 'Moving From the Background Toward the Spotlight: A Critical Review of Radiation Therapy for Locally Advanced Pancreas Cancer', International Journal of Radiation Oncology Biology Physics, vol. 122, no. 2, pp. 294-312. https://doi.org/10.1016/j.ijrobp.2025.02.022

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abstract = "Radiation therapy (RT) for locally advanced pancreatic cancer (LAPC) continues to be controversial. Advances in both systemic therapy and RT techniques have changed the landscape of LAPC management in recent years. Clinical outcomes of ablative RT have been encouraging, and randomized clinical trials may clarify the role of RT for LAPC. We present a contemporary critical review of key aspects regarding optimal patient selection, radiation dose escalation techniques, novel radiosensitizers and radioprotectors, and treatment response assessment for LAPC.",

author = "Chuong, {Michael D.} and Jonathan Ashman and Krishan Jethwa and Jordan Kharofa and Hyun Kim and Eugene Koay and Ethan Ludmir and Eric Miller and Bailey Nelson and Marsha Reyngold and Nina Sanford and Daniel Chang",

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doi = "10.1016/j.ijrobp.2025.02.022",

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AU - Chuong, Michael D.

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AU - Jethwa, Krishan

AU - Kharofa, Jordan

AU - Kim, Hyun

AU - Koay, Eugene

AU - Ludmir, Ethan

AU - Miller, Eric

AU - Nelson, Bailey

AU - Reyngold, Marsha

AU - Sanford, Nina

AU - Chang, Daniel

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AB - Radiation therapy (RT) for locally advanced pancreatic cancer (LAPC) continues to be controversial. Advances in both systemic therapy and RT techniques have changed the landscape of LAPC management in recent years. Clinical outcomes of ablative RT have been encouraging, and randomized clinical trials may clarify the role of RT for LAPC. We present a contemporary critical review of key aspects regarding optimal patient selection, radiation dose escalation techniques, novel radiosensitizers and radioprotectors, and treatment response assessment for LAPC.

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Moving From the Background Toward the Spotlight: A Critical Review of Radiation Therapy for Locally Advanced Pancreas Cancer

Abstract

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