Mouse models in bone marrow transplantation and adoptive cellular therapy

Caroline Arber, Malcolm K. Brenner, Pavan Reddy

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Mouse models of transplantation have been indispensable to the development of bone marrow transplantation (BMT). Their role in the generation of basic science knowledge is invaluable and is subject to discussion below. However, this article focuses on the direct role and relevance of mouse models towards the clinical development and advances in BMT and adoptive T-cell therapy for human diseases. The authors aim to present a thoughtful perspective on the pros and cons of mouse models while noting that despite imperfections these models are obligatory for the development of science-based medicine.

Original languageEnglish (US)
Pages (from-to)131-144
Number of pages14
JournalSeminars in hematology
Volume50
Issue number2
DOIs
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Hematology

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