Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens

Colin F. Fletcher; Hirotaka J. Okano; Debra J. Gilbert; Yolanda Yang; Chingwen Yang; Neal G. Copeland; Nancy A. Jenkins; Robert B. Darnell

doi:10.1006/geno.1997.4925

Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens

Colin F. Fletcher, Hirotaka J. Okano, Debra J. Gilbert, Yolanda Yang, Chingwen Yang, Neal G. Copeland, Nancy A. Jenkins, Robert B. Darnell

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The paraneoplastic neurologic disorders (PND) are a rare group of neurologic syndromes that arise when an immune response to systemic tumors expressing neuronal proteins ('onconeural antigens') develops into an autoimmune neuronal degeneration. The use of patient antisera to clone the genes encoding PND antigens has led to new insight into the mechanism of these autoimmune disorders. The tumor antigens can now be grouped into three classes: (1) neuron-specific RNA-binding proteins, (2) nerve terminal vesicle-associated proteins, and (3) cytoplasmic signaling proteins. To understand better the evolutionary relatedness of these genes and to evaluate them as candidates for inherited neurological disorders, we have determined the mouse chromosomal locations of nine of these genes-Hua, Hub, Huc, Hud, Nova1, Nova2, Natpb, Cdr2, and Cdr3. These data suggest that the Hua-Hud genes arose from gene duplication and dispersion, while the other genes are dispersed in the genome. We also predict the chromosomal locations of these genes in human and discuss the potential of these genes as candidates for uncloned mouse and human mutations.

Original language	English (US)
Pages (from-to)	313-319
Number of pages	7
Journal	Genomics
Volume	45
Issue number	2
DOIs	https://doi.org/10.1006/geno.1997.4925
State	Published - 1997

ASJC Scopus subject areas

Genetics

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@article{0b46f3de12354128b483d809d0b12151,

title = "Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens",

abstract = "The paraneoplastic neurologic disorders (PND) are a rare group of neurologic syndromes that arise when an immune response to systemic tumors expressing neuronal proteins ('onconeural antigens') develops into an autoimmune neuronal degeneration. The use of patient antisera to clone the genes encoding PND antigens has led to new insight into the mechanism of these autoimmune disorders. The tumor antigens can now be grouped into three classes: (1) neuron-specific RNA-binding proteins, (2) nerve terminal vesicle-associated proteins, and (3) cytoplasmic signaling proteins. To understand better the evolutionary relatedness of these genes and to evaluate them as candidates for inherited neurological disorders, we have determined the mouse chromosomal locations of nine of these genes-Hua, Hub, Huc, Hud, Nova1, Nova2, Natpb, Cdr2, and Cdr3. These data suggest that the Hua-Hud genes arose from gene duplication and dispersion, while the other genes are dispersed in the genome. We also predict the chromosomal locations of these genes in human and discuss the potential of these genes as candidates for uncloned mouse and human mutations.",

author = "Fletcher, {Colin F.} and Okano, {Hirotaka J.} and Gilbert, {Debra J.} and Yolanda Yang and Chingwen Yang and Copeland, {Neal G.} and Jenkins, {Nancy A.} and Darnell, {Robert B.}",

note = "Funding Information: This research was supported, in part, by the National Cancer Institute, DHHS, under contract with ABL, and by grants to R.B.D. from the NINDS (RO1 NS34389), the Irma T. Hirschl Trust, and the Department of Defense Breast Cancer Research Award DAMD 017-94-J-4277. H.J.O. was supported by NRSA Postdoctoral Training Grant CA 09673-18, Y.Y.L.Y. was supported by NRSA Training Grant CA 09673-18, and C.Y. was supported by the Cancer Research Insitute Oliver R. Grace Endowed Fellowship.",

year = "1997",

doi = "10.1006/geno.1997.4925",

language = "English (US)",

volume = "45",

pages = "313--319",

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T1 - Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens

AU - Fletcher, Colin F.

AU - Okano, Hirotaka J.

AU - Gilbert, Debra J.

AU - Yang, Yolanda

AU - Yang, Chingwen

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Darnell, Robert B.

N1 - Funding Information: This research was supported, in part, by the National Cancer Institute, DHHS, under contract with ABL, and by grants to R.B.D. from the NINDS (RO1 NS34389), the Irma T. Hirschl Trust, and the Department of Defense Breast Cancer Research Award DAMD 017-94-J-4277. H.J.O. was supported by NRSA Postdoctoral Training Grant CA 09673-18, Y.Y.L.Y. was supported by NRSA Training Grant CA 09673-18, and C.Y. was supported by the Cancer Research Insitute Oliver R. Grace Endowed Fellowship.

PY - 1997

Y1 - 1997

N2 - The paraneoplastic neurologic disorders (PND) are a rare group of neurologic syndromes that arise when an immune response to systemic tumors expressing neuronal proteins ('onconeural antigens') develops into an autoimmune neuronal degeneration. The use of patient antisera to clone the genes encoding PND antigens has led to new insight into the mechanism of these autoimmune disorders. The tumor antigens can now be grouped into three classes: (1) neuron-specific RNA-binding proteins, (2) nerve terminal vesicle-associated proteins, and (3) cytoplasmic signaling proteins. To understand better the evolutionary relatedness of these genes and to evaluate them as candidates for inherited neurological disorders, we have determined the mouse chromosomal locations of nine of these genes-Hua, Hub, Huc, Hud, Nova1, Nova2, Natpb, Cdr2, and Cdr3. These data suggest that the Hua-Hud genes arose from gene duplication and dispersion, while the other genes are dispersed in the genome. We also predict the chromosomal locations of these genes in human and discuss the potential of these genes as candidates for uncloned mouse and human mutations.

AB - The paraneoplastic neurologic disorders (PND) are a rare group of neurologic syndromes that arise when an immune response to systemic tumors expressing neuronal proteins ('onconeural antigens') develops into an autoimmune neuronal degeneration. The use of patient antisera to clone the genes encoding PND antigens has led to new insight into the mechanism of these autoimmune disorders. The tumor antigens can now be grouped into three classes: (1) neuron-specific RNA-binding proteins, (2) nerve terminal vesicle-associated proteins, and (3) cytoplasmic signaling proteins. To understand better the evolutionary relatedness of these genes and to evaluate them as candidates for inherited neurological disorders, we have determined the mouse chromosomal locations of nine of these genes-Hua, Hub, Huc, Hud, Nova1, Nova2, Natpb, Cdr2, and Cdr3. These data suggest that the Hua-Hud genes arose from gene duplication and dispersion, while the other genes are dispersed in the genome. We also predict the chromosomal locations of these genes in human and discuss the potential of these genes as candidates for uncloned mouse and human mutations.

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Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens

Abstract

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