Mouse chromosomal location of three EGF receptor ligands: Amphiregulin (areg), betacellulin (btc), and heparin-binding EGF (hegfl)

Bhavani G. Pathak; Debra J. Gilbert; Charles A. Harrison; Noreen C. Luetteke; Xiaorong Chen; Michael Klagsbrun; Gregory D. Plowman; Neal G. Copeland; Nancy A. Jenkins; David C. Lee

doi:10.1006/geno.1995.1116

Mouse chromosomal location of three EGF receptor ligands: Amphiregulin (areg), betacellulin (btc), and heparin-binding EGF (hegfl)

Bhavani G. Pathak, Debra J. Gilbert, Charles A. Harrison, Noreen C. Luetteke, Xiaorong Chen, Michael Klagsbrun, Gregory D. Plowman, Neal G. Copeland, Nancy A. Jenkins, David C. Lee

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The products of five distinct loci, Egf, Tgfa, Areg, Btc, and Hegfl act as ligands for the epidermal growth factor receptor. Egf and Tgfa have previously been mapped to mouse chromosomes 3 and 6, respectively, hut the mouse chromosomal locations of Areg, Btc, and Hegfl have not been reported. Here, we show that Areg and Btc are tightly linked on mouse chromosome 5, while Hegfl maps to mouse chromosome 18. We also provide evidence that a putative sixth family member, Sdgf, is in fact a species variant of Areg. These results confirm and extend known relationships between mouse and human chromosomes, and they also provide new information regarding the evolution of this important gene family.

Original language	English (US)
Pages (from-to)	116-118
Number of pages	3
Journal	Genomics
Volume	28
Issue number	1
DOIs	https://doi.org/10.1006/geno.1995.1116
State	Published - Jul 1 1995

ASJC Scopus subject areas

Genetics

Access to Document

10.1006/geno.1995.1116

Cite this

@article{3dfd9c58857c42cdb4938a41b6fdd91d,

title = "Mouse chromosomal location of three EGF receptor ligands: Amphiregulin (areg), betacellulin (btc), and heparin-binding EGF (hegfl)",

abstract = "The products of five distinct loci, Egf, Tgfa, Areg, Btc, and Hegfl act as ligands for the epidermal growth factor receptor. Egf and Tgfa have previously been mapped to mouse chromosomes 3 and 6, respectively, hut the mouse chromosomal locations of Areg, Btc, and Hegfl have not been reported. Here, we show that Areg and Btc are tightly linked on mouse chromosome 5, while Hegfl maps to mouse chromosome 18. We also provide evidence that a putative sixth family member, Sdgf, is in fact a species variant of Areg. These results confirm and extend known relationships between mouse and human chromosomes, and they also provide new information regarding the evolution of this important gene family.",

author = "Pathak, \{Bhavani G.\} and Gilbert, \{Debra J.\} and Harrison, \{Charles A.\} and Luetteke, \{Noreen C.\} and Xiaorong Chen and Michael Klagsbrun and Plowman, \{Gregory D.\} and Copeland, \{Neal G.\} and Jenkins, \{Nancy A.\} and Lee, \{David C.\}",

year = "1995",

month = jul,

day = "1",

doi = "10.1006/geno.1995.1116",

language = "English (US)",

volume = "28",

pages = "116--118",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press",

number = "1",

}

TY - JOUR

T1 - Mouse chromosomal location of three EGF receptor ligands

T2 - Amphiregulin (areg), betacellulin (btc), and heparin-binding EGF (hegfl)

AU - Pathak, Bhavani G.

AU - Gilbert, Debra J.

AU - Harrison, Charles A.

AU - Luetteke, Noreen C.

AU - Chen, Xiaorong

AU - Klagsbrun, Michael

AU - Plowman, Gregory D.

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Lee, David C.

PY - 1995/7/1

Y1 - 1995/7/1

N2 - The products of five distinct loci, Egf, Tgfa, Areg, Btc, and Hegfl act as ligands for the epidermal growth factor receptor. Egf and Tgfa have previously been mapped to mouse chromosomes 3 and 6, respectively, hut the mouse chromosomal locations of Areg, Btc, and Hegfl have not been reported. Here, we show that Areg and Btc are tightly linked on mouse chromosome 5, while Hegfl maps to mouse chromosome 18. We also provide evidence that a putative sixth family member, Sdgf, is in fact a species variant of Areg. These results confirm and extend known relationships between mouse and human chromosomes, and they also provide new information regarding the evolution of this important gene family.

AB - The products of five distinct loci, Egf, Tgfa, Areg, Btc, and Hegfl act as ligands for the epidermal growth factor receptor. Egf and Tgfa have previously been mapped to mouse chromosomes 3 and 6, respectively, hut the mouse chromosomal locations of Areg, Btc, and Hegfl have not been reported. Here, we show that Areg and Btc are tightly linked on mouse chromosome 5, while Hegfl maps to mouse chromosome 18. We also provide evidence that a putative sixth family member, Sdgf, is in fact a species variant of Areg. These results confirm and extend known relationships between mouse and human chromosomes, and they also provide new information regarding the evolution of this important gene family.

UR - https://www.scopus.com/pages/publications/0029120892

UR - https://www.scopus.com/inward/citedby.url?scp=0029120892&partnerID=8YFLogxK

U2 - 10.1006/geno.1995.1116

DO - 10.1006/geno.1995.1116

M3 - Article

C2 - 7590736

AN - SCOPUS:0029120892

SN - 0888-7543

VL - 28

SP - 116

EP - 118

JO - Genomics

JF - Genomics

IS - 1

ER -

Mouse chromosomal location of three EGF receptor ligands: Amphiregulin (areg), betacellulin (btc), and heparin-binding EGF (hegfl)

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this