TY - JOUR
T1 - Mouse chromosomal location of three EGF receptor ligands
T2 - Amphiregulin (areg), betacellulin (btc), and heparin-binding EGF (hegfl)
AU - Pathak, Bhavani G.
AU - Gilbert, Debra J.
AU - Harrison, Charles A.
AU - Luetteke, Noreen C.
AU - Chen, Xiaorong
AU - Klagsbrun, Michael
AU - Plowman, Gregory D.
AU - Copeland, Neal G.
AU - Jenkins, Nancy A.
AU - Lee, David C.
PY - 1995/7/1
Y1 - 1995/7/1
N2 - The products of five distinct loci, Egf, Tgfa, Areg, Btc, and Hegfl act as ligands for the epidermal growth factor receptor. Egf and Tgfa have previously been mapped to mouse chromosomes 3 and 6, respectively, hut the mouse chromosomal locations of Areg, Btc, and Hegfl have not been reported. Here, we show that Areg and Btc are tightly linked on mouse chromosome 5, while Hegfl maps to mouse chromosome 18. We also provide evidence that a putative sixth family member, Sdgf, is in fact a species variant of Areg. These results confirm and extend known relationships between mouse and human chromosomes, and they also provide new information regarding the evolution of this important gene family.
AB - The products of five distinct loci, Egf, Tgfa, Areg, Btc, and Hegfl act as ligands for the epidermal growth factor receptor. Egf and Tgfa have previously been mapped to mouse chromosomes 3 and 6, respectively, hut the mouse chromosomal locations of Areg, Btc, and Hegfl have not been reported. Here, we show that Areg and Btc are tightly linked on mouse chromosome 5, while Hegfl maps to mouse chromosome 18. We also provide evidence that a putative sixth family member, Sdgf, is in fact a species variant of Areg. These results confirm and extend known relationships between mouse and human chromosomes, and they also provide new information regarding the evolution of this important gene family.
UR - http://www.scopus.com/inward/record.url?scp=0029120892&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029120892&partnerID=8YFLogxK
U2 - 10.1006/geno.1995.1116
DO - 10.1006/geno.1995.1116
M3 - Article
C2 - 7590736
AN - SCOPUS:0029120892
VL - 28
SP - 116
EP - 118
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 1
ER -