Mouse chromosomal location of three EGF receptor ligands: Amphiregulin (areg), betacellulin (btc), and heparin-binding EGF (hegfl)

Bhavani G. Pathak; Debra J. Gilbert; Charles A. Harrison; Noreen C. Luetteke; Xiaorong Chen; Michael Klagsbrun; Gregory D. Plowman; Neal G. Copeland; Nancy A. Jenkins; David C. Lee

doi:10.1006/geno.1995.1116

Mouse chromosomal location of three EGF receptor ligands: Amphiregulin (areg), betacellulin (btc), and heparin-binding EGF (hegfl)

Bhavani G. Pathak, Debra J. Gilbert, Charles A. Harrison, Noreen C. Luetteke, Xiaorong Chen, Michael Klagsbrun, Gregory D. Plowman, Neal G. Copeland, Nancy A. Jenkins, David C. Lee

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The products of five distinct loci, Egf, Tgfa, Areg, Btc, and Hegfl act as ligands for the epidermal growth factor receptor. Egf and Tgfa have previously been mapped to mouse chromosomes 3 and 6, respectively, hut the mouse chromosomal locations of Areg, Btc, and Hegfl have not been reported. Here, we show that Areg and Btc are tightly linked on mouse chromosome 5, while Hegfl maps to mouse chromosome 18. We also provide evidence that a putative sixth family member, Sdgf, is in fact a species variant of Areg. These results confirm and extend known relationships between mouse and human chromosomes, and they also provide new information regarding the evolution of this important gene family.

Original language	English (US)
Pages (from-to)	116-118
Number of pages	3
Journal	Genomics
Volume	28
Issue number	1
DOIs	https://doi.org/10.1006/geno.1995.1116
State	Published - Jul 1 1995

ASJC Scopus subject areas

Genetics

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10.1006/geno.1995.1116

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Mouse chromosomal location of three EGF receptor ligands : Amphiregulin (areg), betacellulin (btc), and heparin-binding EGF (hegfl). / Pathak, Bhavani G.; Gilbert, Debra J.; Harrison, Charles A.; Luetteke, Noreen C.; Chen, Xiaorong; Klagsbrun, Michael; Plowman, Gregory D.; Copeland, Neal G.; Jenkins, Nancy A.; Lee, David C.

In: Genomics, Vol. 28, No. 1, 01.07.1995, p. 116-118.

Research output: Contribution to journal › Article › peer-review

Pathak, Bhavani G. ; Gilbert, Debra J. ; Harrison, Charles A. ; Luetteke, Noreen C. ; Chen, Xiaorong ; Klagsbrun, Michael ; Plowman, Gregory D. ; Copeland, Neal G. ; Jenkins, Nancy A. ; Lee, David C. / Mouse chromosomal location of three EGF receptor ligands : Amphiregulin (areg), betacellulin (btc), and heparin-binding EGF (hegfl). In: Genomics. 1995 ; Vol. 28, No. 1. pp. 116-118.

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abstract = "The products of five distinct loci, Egf, Tgfa, Areg, Btc, and Hegfl act as ligands for the epidermal growth factor receptor. Egf and Tgfa have previously been mapped to mouse chromosomes 3 and 6, respectively, hut the mouse chromosomal locations of Areg, Btc, and Hegfl have not been reported. Here, we show that Areg and Btc are tightly linked on mouse chromosome 5, while Hegfl maps to mouse chromosome 18. We also provide evidence that a putative sixth family member, Sdgf, is in fact a species variant of Areg. These results confirm and extend known relationships between mouse and human chromosomes, and they also provide new information regarding the evolution of this important gene family.",

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AU - Harrison, Charles A.

AU - Luetteke, Noreen C.

AU - Chen, Xiaorong

AU - Klagsbrun, Michael

AU - Plowman, Gregory D.

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

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AB - The products of five distinct loci, Egf, Tgfa, Areg, Btc, and Hegfl act as ligands for the epidermal growth factor receptor. Egf and Tgfa have previously been mapped to mouse chromosomes 3 and 6, respectively, hut the mouse chromosomal locations of Areg, Btc, and Hegfl have not been reported. Here, we show that Areg and Btc are tightly linked on mouse chromosome 5, while Hegfl maps to mouse chromosome 18. We also provide evidence that a putative sixth family member, Sdgf, is in fact a species variant of Areg. These results confirm and extend known relationships between mouse and human chromosomes, and they also provide new information regarding the evolution of this important gene family.

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Mouse chromosomal location of three EGF receptor ligands: Amphiregulin (areg), betacellulin (btc), and heparin-binding EGF (hegfl)

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