Mouse chromosomal location of three EGF receptor ligands: Amphiregulin (areg), betacellulin (btc), and heparin-binding EGF (hegfl)

Bhavani G. Pathak, Debra J. Gilbert, Charles A. Harrison, Noreen C. Luetteke, Xiaorong Chen, Michael Klagsbrun, Gregory D. Plowman, Neal G. Copeland, Nancy A. Jenkins, David C. Lee

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The products of five distinct loci, Egf, Tgfa, Areg, Btc, and Hegfl act as ligands for the epidermal growth factor receptor. Egf and Tgfa have previously been mapped to mouse chromosomes 3 and 6, respectively, hut the mouse chromosomal locations of Areg, Btc, and Hegfl have not been reported. Here, we show that Areg and Btc are tightly linked on mouse chromosome 5, while Hegfl maps to mouse chromosome 18. We also provide evidence that a putative sixth family member, Sdgf, is in fact a species variant of Areg. These results confirm and extend known relationships between mouse and human chromosomes, and they also provide new information regarding the evolution of this important gene family.

Original languageEnglish (US)
Pages (from-to)116-118
Number of pages3
JournalGenomics
Volume28
Issue number1
DOIs
StatePublished - Jul 1 1995

ASJC Scopus subject areas

  • Genetics

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