Mouse annexin III cDNA, genetic mapping and evolution

Maria Pilar Fernández; Neal G. Copeland; Debra J. Gilbert; Nancy A. Jenkins; Reginald O. Morgan

doi:10.1016/S0378-1119(97)00602-1

Mouse annexin III cDNA, genetic mapping and evolution

Maria Pilar Fernández, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Reginald O. Morgan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Mouse annexin III cDNA was characterized from I.M.A.G.E. Consortium (LLNL) expressed sequence tag clones by molecular sequencing, chromosomal mapping and systematic analysis. cDNA sequences extended the known 5' and 3' untranslated regions and confirmed the location of intron 7 with respect to the human gene. The Anx3 locus mapped to the middle of mouse chromosome 5 between Areg and Fgf5. Protein-coding regions were compared with homologous annexins to establish subfamily identity, structural conservation and divergence pattern. Anexin III exhibited low functional constraint against structural change and weak phylogenetic association with known annexins. The rapid, constant divergence of human and rodent annexins III from each other and from other annexin subfamilies was used to estimate gene separation times. Phylogenetic, phenetic and structural data suggested a possible direct or indirect separation of annexin III from XI approximately 317 million years ago.

Original language	English (US)
Pages (from-to)	43-51
Number of pages	9
Journal	Gene
Volume	207
Issue number	1
DOIs	https://doi.org/10.1016/S0378-1119(97)00602-1
State	Published - Jan 19 1998

Keywords

Chromosomal localization
Gene duplication
Genetic linkage map
Molecular evolution
Molecular sequence data
Nucleotide substitution rates

ASJC Scopus subject areas

Genetics

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10.1016/S0378-1119(97)00602-1

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title = "Mouse annexin III cDNA, genetic mapping and evolution",

abstract = "Mouse annexin III cDNA was characterized from I.M.A.G.E. Consortium (LLNL) expressed sequence tag clones by molecular sequencing, chromosomal mapping and systematic analysis. cDNA sequences extended the known 5' and 3' untranslated regions and confirmed the location of intron 7 with respect to the human gene. The Anx3 locus mapped to the middle of mouse chromosome 5 between Areg and Fgf5. Protein-coding regions were compared with homologous annexins to establish subfamily identity, structural conservation and divergence pattern. Anexin III exhibited low functional constraint against structural change and weak phylogenetic association with known annexins. The rapid, constant divergence of human and rodent annexins III from each other and from other annexin subfamilies was used to estimate gene separation times. Phylogenetic, phenetic and structural data suggested a possible direct or indirect separation of annexin III from XI approximately 317 million years ago.",

keywords = "Chromosomal localization, Gene duplication, Genetic linkage map, Molecular evolution, Molecular sequence data, Nucleotide substitution rates",

author = "Fern{\'a}ndez, {Maria Pilar} and Copeland, {Neal G.} and Gilbert, {Debra J.} and Jenkins, {Nancy A.} and Morgan, {Reginald O.}",

note = "Funding Information: We thank Deborah B. Householder for excellent technical assistance, and Drs Wen-Hsiung Li and Julia Krushkal for providing the program to calculate nucleotide substitution rates. EST clones from the I.M.A.G.E. Consortium (Lawrence Livermore National Laboratory) were provided by the United Kingdom Human Genome Mapping Project Resource Centre, Hinxton, UK. This work was supported by grant PM95-0152 from DGES of Spain, and by the National Cancer Institute, DHHS, under contract with ABL. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

year = "1998",

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doi = "10.1016/S0378-1119(97)00602-1",

language = "English (US)",

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AU - Fernández, Maria Pilar

AU - Copeland, Neal G.

AU - Gilbert, Debra J.

AU - Jenkins, Nancy A.

AU - Morgan, Reginald O.

N1 - Funding Information: We thank Deborah B. Householder for excellent technical assistance, and Drs Wen-Hsiung Li and Julia Krushkal for providing the program to calculate nucleotide substitution rates. EST clones from the I.M.A.G.E. Consortium (Lawrence Livermore National Laboratory) were provided by the United Kingdom Human Genome Mapping Project Resource Centre, Hinxton, UK. This work was supported by grant PM95-0152 from DGES of Spain, and by the National Cancer Institute, DHHS, under contract with ABL. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 1998/1/19

Y1 - 1998/1/19

N2 - Mouse annexin III cDNA was characterized from I.M.A.G.E. Consortium (LLNL) expressed sequence tag clones by molecular sequencing, chromosomal mapping and systematic analysis. cDNA sequences extended the known 5' and 3' untranslated regions and confirmed the location of intron 7 with respect to the human gene. The Anx3 locus mapped to the middle of mouse chromosome 5 between Areg and Fgf5. Protein-coding regions were compared with homologous annexins to establish subfamily identity, structural conservation and divergence pattern. Anexin III exhibited low functional constraint against structural change and weak phylogenetic association with known annexins. The rapid, constant divergence of human and rodent annexins III from each other and from other annexin subfamilies was used to estimate gene separation times. Phylogenetic, phenetic and structural data suggested a possible direct or indirect separation of annexin III from XI approximately 317 million years ago.

AB - Mouse annexin III cDNA was characterized from I.M.A.G.E. Consortium (LLNL) expressed sequence tag clones by molecular sequencing, chromosomal mapping and systematic analysis. cDNA sequences extended the known 5' and 3' untranslated regions and confirmed the location of intron 7 with respect to the human gene. The Anx3 locus mapped to the middle of mouse chromosome 5 between Areg and Fgf5. Protein-coding regions were compared with homologous annexins to establish subfamily identity, structural conservation and divergence pattern. Anexin III exhibited low functional constraint against structural change and weak phylogenetic association with known annexins. The rapid, constant divergence of human and rodent annexins III from each other and from other annexin subfamilies was used to estimate gene separation times. Phylogenetic, phenetic and structural data suggested a possible direct or indirect separation of annexin III from XI approximately 317 million years ago.

KW - Chromosomal localization

KW - Gene duplication

KW - Genetic linkage map

KW - Molecular evolution

KW - Molecular sequence data

KW - Nucleotide substitution rates

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Mouse annexin III cDNA, genetic mapping and evolution

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Keywords

ASJC Scopus subject areas

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