Mouse A-myb encodes a trans-activator and is expressed in mitotically active cells of the developing central nervous system, adult testis and B lymphocytes

Konrad Trauth, Bettina Mutschier, Nancy A. Jenkins, Debra J. Gilbert, Neal G. Copeland, Karl Heinz Klempnauer

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

C-myb encodes a transcriptional activator that is essential for the development of the hematopoietic system but appears to lack major roles in non-hematopoietic cells. The identification of two conserved myb- related genes, designated A-myb and B-myb, has raised the possibility that these genes are functional equivalents of c-myb in non-hematopoietic cells. Here, we report the isolation and preliminary characterization of the mouse A-myb gene. Mouse A-myb maps to the proximal region of chromosome 1 and encodes a transcriptional activator with properties similar to those of the c-myb and v-myb proteins. During embryogenesis A-myb is predominantly expressed in several regions of the developing central nervous system (CNS) and the urogenital ridge. Expression in the CNS is confined to the neural tube, the hindbrain, the neural retina and the olfactory epithelium, and coincides with the presence of proliferating immature neuronal precursor cells. In the adult mouse, A-myb is expressed during the early stages of sperm cell differentiation and in B lymphocytes located in germinal centers of the spleen. Taken together, these results suggest a role for A-myb in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.

Original languageEnglish (US)
Pages (from-to)5994-6005
Number of pages12
JournalEMBO Journal
Volume13
Issue number24
DOIs
StatePublished - Dec 15 1994

Keywords

  • Mouse A-myblmyb-related gene
  • Neuronal differentiation
  • Spermatogenesis
  • Trans-activation

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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