Motor neuron disease on Guam: temporal xcurrence, 1941–85

Z. X. Zhang, D. W. Anderson, N. Mantel, Gustavo C. Roman

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Using a case registry, we investigated the temporal occurrence of motor neuron disease (MND) on Guam. MND with onset during 1941-85 was documented in 434 Chamorros and 9 non-Chamorro migrants who had lived on Guam before onset. Increased median age at onset and decreased age-adjusted incidence rates (since the early 1960s) were observed for Chamorros of both sexes. Our evidence about MND on Guam is consistent with: 1) The latent period duration has varied from years to decades; 2) With time, the exposure period or latent period, or both, have lengthened; 3) The high risk of acquiring the condition has been reduced since, at least, the early 1950s, and the most recent years of meaningful risk were the early to middle 1960s; 4) The critical age for acquiring the condition is in adolescence and adulthood; 5) Change of environment from Guam to overseas during childhood resulted in decreased risk of acquiring the condition.

Original languageEnglish (US)
Pages (from-to)299-307
Number of pages9
JournalActa Neurologica Scandinavica
Issue number4
StatePublished - Jan 1 1995


  • Case registry
  • Cohort
  • Epidemiology
  • Incidence
  • Motor neuron disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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