Morphologically virus-like fullerenol nanoparticles act as the dual-functional nanoadjuvant for HIV-1 vaccine

Ligeng Xu, Ye Liu, Zhiyun Chen, Wei Li, Ying Liu, Liming Wang, Liying Ma, Yiming Shao, Yuliang Zhao, Chunying Chen

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Fullerenol, which self-assembles into virus-sized nanoparticles, is designed as a dual-functional nanoadjuvant to generate comparable immune responses to the HIV DNA vaccine. It shows promising adjuvant activity via various immunization routes, decreasing the antigen dosage and immunization frequency while maintaining immunity levels and inducing TEM-biased immunity to combat the infection at early stage. The underlying mechanisms by which fullerenol-based formulation induces above-mentioned polyvalent immune responses are involved in activating multiple TLRs signaling pathways.

Original languageEnglish (US)
Pages (from-to)5928-5936
Number of pages9
JournalAdvanced Materials
Volume25
Issue number41
DOIs
StatePublished - Nov 6 2013

Keywords

  • fullerenol
  • HIV-1
  • nano-adjuvant
  • vaccine
  • virus-like particle

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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