Morphologically virus-like fullerenol nanoparticles act as the dual-functional nanoadjuvant for HIV-1 vaccine

Ligeng Xu; Ye Liu; Zhiyun Chen; Wei Li; Ying Liu; Liming Wang; Liying Ma; Yiming Shao; Yuliang Zhao; Chunying Chen

doi:10.1002/adma.201300583

Morphologically virus-like fullerenol nanoparticles act as the dual-functional nanoadjuvant for HIV-1 vaccine

Ligeng Xu, Ye Liu, Zhiyun Chen, Wei Li, Ying Liu, Liming Wang, Liying Ma, Yiming Shao, Yuliang Zhao, Chunying Chen

Houston Methodist

Research output: Contribution to journal › Article › peer-review

127 Scopus citations

Abstract

Fullerenol, which self-assembles into virus-sized nanoparticles, is designed as a dual-functional nanoadjuvant to generate comparable immune responses to the HIV DNA vaccine. It shows promising adjuvant activity via various immunization routes, decreasing the antigen dosage and immunization frequency while maintaining immunity levels and inducing T_EM-biased immunity to combat the infection at early stage. The underlying mechanisms by which fullerenol-based formulation induces above-mentioned polyvalent immune responses are involved in activating multiple TLRs signaling pathways.

Original language	English (US)
Pages (from-to)	5928-5936
Number of pages	9
Journal	Advanced Materials
Volume	25
Issue number	41
DOIs	https://doi.org/10.1002/adma.201300583
State	Published - Nov 6 2013

Keywords

fullerenol
HIV-1
nano-adjuvant
vaccine
virus-like particle

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201300583

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abstract = "Fullerenol, which self-assembles into virus-sized nanoparticles, is designed as a dual-functional nanoadjuvant to generate comparable immune responses to the HIV DNA vaccine. It shows promising adjuvant activity via various immunization routes, decreasing the antigen dosage and immunization frequency while maintaining immunity levels and inducing TEM-biased immunity to combat the infection at early stage. The underlying mechanisms by which fullerenol-based formulation induces above-mentioned polyvalent immune responses are involved in activating multiple TLRs signaling pathways.",

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AU - Xu, Ligeng

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AU - Liu, Ying

AU - Wang, Liming

AU - Ma, Liying

AU - Shao, Yiming

AU - Zhao, Yuliang

AU - Chen, Chunying

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AB - Fullerenol, which self-assembles into virus-sized nanoparticles, is designed as a dual-functional nanoadjuvant to generate comparable immune responses to the HIV DNA vaccine. It shows promising adjuvant activity via various immunization routes, decreasing the antigen dosage and immunization frequency while maintaining immunity levels and inducing TEM-biased immunity to combat the infection at early stage. The underlying mechanisms by which fullerenol-based formulation induces above-mentioned polyvalent immune responses are involved in activating multiple TLRs signaling pathways.

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KW - virus-like particle

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Morphologically virus-like fullerenol nanoparticles act as the dual-functional nanoadjuvant for HIV-1 vaccine

Abstract

Keywords

ASJC Scopus subject areas

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