Morphological and hemodynamic discriminators for rupture status in posterior communicating artery aneurysms

Nan Lv, Chi Wang, Christof Karmonik, Yibin Fang, Jinyu Xu, Ying Yu, Wei Cao, Jianmin Liu, Qinghai Huang

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Background and Purpose: The conflicting findings of previous morphological and hemodynamic studies on intracranial aneurysm rupture may be caused by the relatively small sample sizes and the variation in location of the patient-specific aneurysm models. We aimed to determine the discriminators for aneurysm rupture status by focusing on only posterior communicating artery (PCoA) aneurysms. Materials and Methods: In 129 PCoA aneurysms (85 ruptured, 44 unruptured), clinical, morphological and hemodynamic characteristics were compared between the ruptured and unruptured cases. Multivariate logistic regression analysis was performed to determine the discriminators for rupture status of PCoA aneurysms. Results: While univariate analyses showed that the size of aneurysm dome, aspect ratio (AR), size ratio (SR), dome-to-neck ratio (DN), inflow angle (IA), normalized wall shear stress (NWSS) and percentage of low wall shear stress area (LSA) were significantly associated with PCoA aneurysm rupture status. With multivariate analyses, significance was only retained for higher IA (OR = 1.539, p <0.001) and LSA (OR = 1.393, p = 0.041). Conclusions: Hemodynamics and morphology were related to rupture status of intracranial aneurysms. Higher IA and LSA were identified as discriminators for rupture status of PCoA aneurysms.

Original languageEnglish (US)
Article numbere0149906
JournalPLoS ONE
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2016

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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