More complex transcriptional regulation and stress response by MOF

N Horikoshi; C R Hunt; T K Pandita

doi:10.1038/onc.2015.373

More complex transcriptional regulation and stress response by MOF

N Horikoshi, C R Hunt, T K Pandita

Research output: Contribution to journal › Article › peer-review

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Abstract

MOF (males absent on the first) was initially discovered as a dosage compensation factor that regulates the epigenetic acetylation of histone H4 lysine 16. In this issue, Sheikh et al. demonstrate that MOF expression is not required for normal kidney tissue function but is required for maintaining transcriptional regulation under conditions of stress. This work along with results from previous investigators highlights the importance of the cell lineage-chromatin modification interaction in determining transcriptional programs and physiological outcomes under normal and stress conditions.Oncogene advance online publication, 5 October 2015; doi:10.1038/onc.2015.373.

Original language	English (US)
Journal	Oncogene
DOIs	https://doi.org/10.1038/onc.2015.373
State	Published - Oct 5 2015

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abstract = "MOF (males absent on the first) was initially discovered as a dosage compensation factor that regulates the epigenetic acetylation of histone H4 lysine 16. In this issue, Sheikh et al. demonstrate that MOF expression is not required for normal kidney tissue function but is required for maintaining transcriptional regulation under conditions of stress. This work along with results from previous investigators highlights the importance of the cell lineage-chromatin modification interaction in determining transcriptional programs and physiological outcomes under normal and stress conditions.Oncogene advance online publication, 5 October 2015; doi:10.1038/onc.2015.373.",

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AB - MOF (males absent on the first) was initially discovered as a dosage compensation factor that regulates the epigenetic acetylation of histone H4 lysine 16. In this issue, Sheikh et al. demonstrate that MOF expression is not required for normal kidney tissue function but is required for maintaining transcriptional regulation under conditions of stress. This work along with results from previous investigators highlights the importance of the cell lineage-chromatin modification interaction in determining transcriptional programs and physiological outcomes under normal and stress conditions.Oncogene advance online publication, 5 October 2015; doi:10.1038/onc.2015.373.

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More complex transcriptional regulation and stress response by MOF

Abstract

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