Morbidity and mortality of multivisceral resection with radical nephrectomy for locally advanced renal cell carcinoma: An analysis of the National Surgical Quality Improvement Program (NSQIP) database

Kelvin Lim, Carlos Riveros, Sanjana Ranganathan, Jiaqiong Xu, Ashmi Patel, Jeremy Slawin, Adriana Ordonez, Monty Aghazadeh, Monica Morgan, Brian J Miles, Nestor Esnaola, Zachary Klaassen, Kelvin Allenson, Michael Brooks, Christopher J D Wallis, Raj Satkunasivam

Research output: Contribution to journalArticlepeer-review


INTRODUCTION: Locally advanced renal cell carcinoma (RCC) can rarely invade into adjacent abdominal viscera without clinical evidence of distant metastases. The role of multivisceral resection (MVR) of involved adjacent organs at the time of radical nephrectomy (RN) remains poorly described and quantified. Using a national database, we aimed to evaluate the association between RN+MVR and 30-day postoperative complications.

METHODS AND MATERIALS: We conducted a retrospective cohort study of adult patients undergoing RN for RCC with and without MVR between 2005 and 2020 using the ACS-NSQIP database. The primary outcome was a composite of any of the following 30-day major postoperative complications: mortality, reoperation, cardiac event, and neurologic event. Secondary outcomes included individual components of the composite primary outcome, as well as infectious and venous thromboembolic complications, unplanned intubation and ventilation, transfusion, readmission, and prolonged length of stay (LOS). Groups were balanced using propensity score matching. Likelihood of complications was assessed by conditional logistic regression adjusted for unbalanced total operation time. Postoperative complications were compared by Fisher's exact test among subtypes of resection.

RESULTS: A total of 12,417 patients were identified: 12,193 (98.2%) undergoing RN alone and 224 (1.8%) undergoing RN+MVR. Patients undergoing RN+MVR were more likely to experience major complications (odds ratio [OR] 2.46; 95% confidence interval [CI] 1.28-4.74). However, there was no significant association between RN+MVR and postoperative mortality (OR 2.49; 95% CI 0.89-7.01). RN+MVR was associated with higher rates of reoperation (OR 7.85; 95% CI 2.38-25.8), sepsis (OR 5.45; 95% CI 1.83-16.2), surgical site infection (OR 4.41; 95% CI 2.14-9.07), blood transfusion (OR 2.24; 95% CI 1.55-3.22), readmission (OR 1.78; 95% CI 1.11-2.84), infectious complications (OR 2.62; 95% CI 1.62-4.24), and longer hospital stay (5 days [IQR 3-8] vs. 4 days [IQR 3-7]; OR 2.31 [95% CI 2.13-3.03]). There was no heterogeneity in the association between subtype of MVR and major complication rate.

CONCLUSION: Undergoing RN+MVR is associated with an increased risk of 30-day postoperative morbidity, including infectious complications, reoperation, blood transfusion, prolonged LOS, and readmission.

Original languageEnglish (US)
Pages (from-to)209.e1-209.e9
JournalUrologic Oncology: Seminars and Original Investigations
Issue number4
Early online dateFeb 18 2023
StatePublished - Apr 2023


  • Morbidity
  • Mortality
  • Multivisceral resection
  • Radical nephrectomy
  • Renal cell carcinoma
  • Humans
  • Nephrectomy/adverse effects
  • Carcinoma, Renal Cell/complications
  • Quality Improvement
  • Kidney Neoplasms/pathology
  • Postoperative Complications/epidemiology
  • Adult
  • Retrospective Studies

ASJC Scopus subject areas

  • Urology
  • Oncology


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