Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte–macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammation, and foreign body-induced giant cells (FBGCs). The fusion of monocytes/macrophages with tumor cells may promote cancer metastasis. We describe types and examples of monocyte–macrophage lineage cell fusion and the role of actin-based structures in cell fusion.

Original languageEnglish (US)
Article number6553
JournalInternational journal of molecular sciences
Issue number12
StatePublished - Jun 1 2022


  • cell fusion
  • cell protrusions
  • giant cells
  • hematopoietic stem cells
  • macrophage
  • monocyte
  • osteoclast
  • podosomes
  • syncytium
  • tumor-associated macrophages
  • viral fusion

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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