Monitoring of glucose permeability in monkey skin in vivo using Optical Coherence Tomography

Mohamad G. Ghosn; Narendran Sudheendran; Mark Wendt; Adrian Glasser; Valery V. Tuchin; Kirill V. Larin

doi:10.1002/jbio.200910075

Monitoring of glucose permeability in monkey skin in vivo using Optical Coherence Tomography

Mohamad G. Ghosn, Narendran Sudheendran, Mark Wendt, Adrian Glasser, Valery V. Tuchin, Kirill V. Larin

Academic Institute

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Topical trans-dermal delivery of drugs has proven to be a promising route for treatment of many dermatological diseases. The aim of this study is to monitor and quantify the permeability rate of glucose solutions in rhesus monkey skin noninvasively in vivo as a primate model for drug diffusion. A time-domain Optical Coherence Tomography (OCT) system was used to image the diffusion of glucose in the skin of anesthetized monkeys for which the permeability rate was calculated. From 5 experiments on 4 different monkeys, the permeability for glucose-20% was found to be (4.41 ± 0.28) 10^-6 cm/sec. The results suggest that OCT might be utilized for the noninvasive study of molecular diffusion in the multilayered biological tissues in vivo.

Original language	English (US)
Pages (from-to)	25-33
Number of pages	9
Journal	Journal of Biophotonics
Volume	3
Issue number	1-2
DOIs	https://doi.org/10.1002/jbio.200910075
State	Published - 2010

Keywords

Diffusion
Optical coherence tomography
Permeability rate
Skin

ASJC Scopus subject areas

Chemistry(all)
Materials Science(all)
Biochemistry, Genetics and Molecular Biology(all)
Engineering(all)
Physics and Astronomy(all)

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10.1002/jbio.200910075

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title = "Monitoring of glucose permeability in monkey skin in vivo using Optical Coherence Tomography",

abstract = "Topical trans-dermal delivery of drugs has proven to be a promising route for treatment of many dermatological diseases. The aim of this study is to monitor and quantify the permeability rate of glucose solutions in rhesus monkey skin noninvasively in vivo as a primate model for drug diffusion. A time-domain Optical Coherence Tomography (OCT) system was used to image the diffusion of glucose in the skin of anesthetized monkeys for which the permeability rate was calculated. From 5 experiments on 4 different monkeys, the permeability for glucose-20% was found to be (4.41 ± 0.28) 10-6 cm/sec. The results suggest that OCT might be utilized for the noninvasive study of molecular diffusion in the multilayered biological tissues in vivo.",

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AU - Ghosn, Mohamad G.

AU - Sudheendran, Narendran

AU - Wendt, Mark

AU - Glasser, Adrian

AU - Tuchin, Valery V.

AU - Larin, Kirill V.

PY - 2010

Y1 - 2010

N2 - Topical trans-dermal delivery of drugs has proven to be a promising route for treatment of many dermatological diseases. The aim of this study is to monitor and quantify the permeability rate of glucose solutions in rhesus monkey skin noninvasively in vivo as a primate model for drug diffusion. A time-domain Optical Coherence Tomography (OCT) system was used to image the diffusion of glucose in the skin of anesthetized monkeys for which the permeability rate was calculated. From 5 experiments on 4 different monkeys, the permeability for glucose-20% was found to be (4.41 ± 0.28) 10-6 cm/sec. The results suggest that OCT might be utilized for the noninvasive study of molecular diffusion in the multilayered biological tissues in vivo.

AB - Topical trans-dermal delivery of drugs has proven to be a promising route for treatment of many dermatological diseases. The aim of this study is to monitor and quantify the permeability rate of glucose solutions in rhesus monkey skin noninvasively in vivo as a primate model for drug diffusion. A time-domain Optical Coherence Tomography (OCT) system was used to image the diffusion of glucose in the skin of anesthetized monkeys for which the permeability rate was calculated. From 5 experiments on 4 different monkeys, the permeability for glucose-20% was found to be (4.41 ± 0.28) 10-6 cm/sec. The results suggest that OCT might be utilized for the noninvasive study of molecular diffusion in the multilayered biological tissues in vivo.

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Monitoring of glucose permeability in monkey skin in vivo using Optical Coherence Tomography

Abstract

Keywords

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