Monitoring of drug diffusion in ocular tissues

Mohamad G. Ghosn, Yezeng Cheng, Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contribution


There is increasing interest in determining drug diffusion rates in ocular tissues. In this paper we present results of our pilot investigation of depth-resolved monitoring of water diffusion in rabbit cornea using Optical Coherence Tomography (OCT) technique. We monitored changes in the local scattering coefficient of rabbit cornea in vitro as water propagated inside the tissue. Tissue hydration and saturation phases were clearly seen. The water diffusion rate was about 1.48e -5cm/sec. The experimental results suggest that water diffusion rate in cornea can be potentially measured with the OCT system noninvasively with high precision and accuracy.

Original languageEnglish (US)
Title of host publicationSaratov Fall Meeting 2005
Subtitle of host publicationOptical Technologies in Biophysics and Medicine VII
StatePublished - 2006
EventSaratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII - Saratov, Russian Federation
Duration: Sep 27 2005Sep 30 2005

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceSaratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII
Country/TerritoryRussian Federation


  • Diffusion
  • Optical coherence tomography
  • Rabbit cornea

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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