Molecules involved in cell death and peripheral tolerance

Jin Wang, Michael J. Lenardo

    Research output: Contribution to journalArticlepeer-review

    34 Scopus citations

    Abstract

    Apoptosis is important for maintaining peripheral lymphocyte homeostasis and for minimizing the accumulation of autoreactive lymphocytes. Disruption of apoptotic pathways has been linked to lymphadenopathy, breakdown of peripheral tolerance and the development of autoimmune diseases. Major progress has been made during the past year in understanding the critical roles of a variety of signaling molecules, especially a group of cysteine proteases, for the execution of apoptosis. These proteases appear to be the primary effector molecules responsible for carrying out lymphocyte apoptosis and may be critical for peripheral immunological tolerance.

    Original languageEnglish (US)
    Pages (from-to)818-825
    Number of pages8
    JournalCurrent Opinion in Immunology
    Volume9
    Issue number6
    DOIs
    StatePublished - Jan 1 1997

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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