Molecules involved in cell death and peripheral tolerance

Jin Wang, Michael J. Lenardo

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Apoptosis is important for maintaining peripheral lymphocyte homeostasis and for minimizing the accumulation of autoreactive lymphocytes. Disruption of apoptotic pathways has been linked to lymphadenopathy, breakdown of peripheral tolerance and the development of autoimmune diseases. Major progress has been made during the past year in understanding the critical roles of a variety of signaling molecules, especially a group of cysteine proteases, for the execution of apoptosis. These proteases appear to be the primary effector molecules responsible for carrying out lymphocyte apoptosis and may be critical for peripheral immunological tolerance.

Original languageEnglish (US)
Pages (from-to)818-825
Number of pages8
JournalCurrent Opinion in Immunology
Issue number6
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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