Molecular typing of antibiotic-resistant Staphylococcus aureus in Nigeria

S. M. O'Malley; F. E. Emele; F. O. Nwaokorie; N. Idika; A. K. Umeizudike; I. Emeka-Nwabunnia; B. M. Hanson; R. Nair; S. E. Wardyn; T. C. Smith

doi:10.1016/j.jiph.2014.08.001

Molecular typing of antibiotic-resistant Staphylococcus aureus in Nigeria

S. M. O'Malley, F. E. Emele, F. O. Nwaokorie, N. Idika, A. K. Umeizudike, I. Emeka-Nwabunnia, B. M. Hanson, R. Nair, S. E. Wardyn, T. C. Smith

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Background: Antibiotic-resistant Staphylococcus aureus including methicillin-resistant strains (MRSA) are a major concern in densely populated urban areas. Initial studies of S. aureus in Nigeria indicated existence of antibiotic-resistant S. aureus strains in clinical and community settings. Methods: 73 biological samples (40 throat, 23 nasal, 10 wound) were collected from patients and healthcare workers in three populations in Nigeria: Lagos University Teaching Hospital, Nigerian Institute of Medical Research, and Owerri General Hospital. Results: S. aureus was isolated from 38 of 73 samples (52%). Of the 38 S. aureus samples, 9 (24%) carried the Panton-Valentine leukocidin gene (PVL) while 16 (42%) possessed methicillin resistance genes (mecA). Antibiotic susceptibility profiles indicated resistance to several broad-spectrum antibiotics. Conclusion: Antibiotic-resistant S. aureus isolates were recovered from clinical and community settings in Nigeria. Insight about S. aureus in Nigeria may be used to improve antibiotic prescription methods and minimize the spread of antibiotic-resistant organisms in highly populated urban communities similar to Lagos, Nigeria.

Original language	English (US)
Pages (from-to)	187-193
Number of pages	7
Journal	Journal of Infection and Public Health
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/j.jiph.2014.08.001
State	Published - 2015

Keywords

Antibiotic resistance
Epidemiology
MecA
Nigeria
PVL
Spa typing
Staphylococcus aureus

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.jiph.2014.08.001

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title = "Molecular typing of antibiotic-resistant Staphylococcus aureus in Nigeria",

abstract = "Background: Antibiotic-resistant Staphylococcus aureus including methicillin-resistant strains (MRSA) are a major concern in densely populated urban areas. Initial studies of S. aureus in Nigeria indicated existence of antibiotic-resistant S. aureus strains in clinical and community settings. Methods: 73 biological samples (40 throat, 23 nasal, 10 wound) were collected from patients and healthcare workers in three populations in Nigeria: Lagos University Teaching Hospital, Nigerian Institute of Medical Research, and Owerri General Hospital. Results: S. aureus was isolated from 38 of 73 samples (52%). Of the 38 S. aureus samples, 9 (24%) carried the Panton-Valentine leukocidin gene (PVL) while 16 (42%) possessed methicillin resistance genes (mecA). Antibiotic susceptibility profiles indicated resistance to several broad-spectrum antibiotics. Conclusion: Antibiotic-resistant S. aureus isolates were recovered from clinical and community settings in Nigeria. Insight about S. aureus in Nigeria may be used to improve antibiotic prescription methods and minimize the spread of antibiotic-resistant organisms in highly populated urban communities similar to Lagos, Nigeria.",

keywords = "Antibiotic resistance, Epidemiology, MecA, Nigeria, PVL, Spa typing, Staphylococcus aureus",

author = "O'Malley, {S. M.} and Emele, {F. E.} and Nwaokorie, {F. O.} and N. Idika and Umeizudike, {A. K.} and I. Emeka-Nwabunnia and Hanson, {B. M.} and R. Nair and Wardyn, {S. E.} and Smith, {T. C.}",

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year = "2015",

doi = "10.1016/j.jiph.2014.08.001",

language = "English (US)",

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AU - O'Malley, S. M.

AU - Emele, F. E.

AU - Nwaokorie, F. O.

AU - Idika, N.

AU - Umeizudike, A. K.

AU - Emeka-Nwabunnia, I.

AU - Hanson, B. M.

AU - Nair, R.

AU - Wardyn, S. E.

AU - Smith, T. C.

PY - 2015

Y1 - 2015

N2 - Background: Antibiotic-resistant Staphylococcus aureus including methicillin-resistant strains (MRSA) are a major concern in densely populated urban areas. Initial studies of S. aureus in Nigeria indicated existence of antibiotic-resistant S. aureus strains in clinical and community settings. Methods: 73 biological samples (40 throat, 23 nasal, 10 wound) were collected from patients and healthcare workers in three populations in Nigeria: Lagos University Teaching Hospital, Nigerian Institute of Medical Research, and Owerri General Hospital. Results: S. aureus was isolated from 38 of 73 samples (52%). Of the 38 S. aureus samples, 9 (24%) carried the Panton-Valentine leukocidin gene (PVL) while 16 (42%) possessed methicillin resistance genes (mecA). Antibiotic susceptibility profiles indicated resistance to several broad-spectrum antibiotics. Conclusion: Antibiotic-resistant S. aureus isolates were recovered from clinical and community settings in Nigeria. Insight about S. aureus in Nigeria may be used to improve antibiotic prescription methods and minimize the spread of antibiotic-resistant organisms in highly populated urban communities similar to Lagos, Nigeria.

AB - Background: Antibiotic-resistant Staphylococcus aureus including methicillin-resistant strains (MRSA) are a major concern in densely populated urban areas. Initial studies of S. aureus in Nigeria indicated existence of antibiotic-resistant S. aureus strains in clinical and community settings. Methods: 73 biological samples (40 throat, 23 nasal, 10 wound) were collected from patients and healthcare workers in three populations in Nigeria: Lagos University Teaching Hospital, Nigerian Institute of Medical Research, and Owerri General Hospital. Results: S. aureus was isolated from 38 of 73 samples (52%). Of the 38 S. aureus samples, 9 (24%) carried the Panton-Valentine leukocidin gene (PVL) while 16 (42%) possessed methicillin resistance genes (mecA). Antibiotic susceptibility profiles indicated resistance to several broad-spectrum antibiotics. Conclusion: Antibiotic-resistant S. aureus isolates were recovered from clinical and community settings in Nigeria. Insight about S. aureus in Nigeria may be used to improve antibiotic prescription methods and minimize the spread of antibiotic-resistant organisms in highly populated urban communities similar to Lagos, Nigeria.

KW - Antibiotic resistance

KW - Epidemiology

KW - MecA

KW - Nigeria

KW - PVL

KW - Spa typing

KW - Staphylococcus aureus

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Molecular typing of antibiotic-resistant Staphylococcus aureus in Nigeria

Abstract

Keywords

ASJC Scopus subject areas

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