Molecular targets of quercetin with anti-inflammatory properties in atopic dermatitis

Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Remya Sreedhar, Vijayasree V. Giridharan, Kenichi Watanabe

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

Atopic dermatitis (AD) is an inflammatory skin disease. Over the past few decades, AD has become more prevalent worldwide. Quercetin, a naturally occurring polyphenol, shows antioxidant, anti-inflammatory, and antiallergic activities. Several recent clinical and preclinical findings suggest quercetin as a promising natural treatment for inflammatory skin diseases. Significant progress in elucidating the molecular mechanisms underlying the anti-AD properties of quercetin has been achieved in the recent years. Here, we discuss the use of quercetin as treatment for AD, with a particular focus on the molecular basis of its effect. We also briefly discuss the approaches to improve the bioavailability of quercetin.

Original languageEnglish (US)
Pages (from-to)632-639
Number of pages8
JournalDrug Discovery Today
Volume21
Issue number4
DOIs
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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