Molecular mediators of liver ischemia and reperfusion injury: A brief review

Andrew J. Vardanian, Ronald W. Busuttil, Jerzy W. Kupiec-Weglinski

Research output: Contribution to journalShort surveypeer-review

139 Scopus citations


Ischemia and reperfusion injury is a dynamic process that involves multiple organ systems in various clinical states including transplantation, trauma, and surgery. Research into this field has identified key molecular and signaling players that mediate, modulate, or augment cellular, tissue, and organ injury during this disease process. Further elucidation of the molecular mechanisms should provide the rationale to identify much-needed novel therapeutic options to prevent or ameliorate organ damage due to ischemia and reperfusion in clinics.

Original languageEnglish (US)
Pages (from-to)337-345
Number of pages9
JournalMolecular Medicine
Issue number5-6
StatePublished - May 2008

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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