Molecular Imaging of Blood–Brain Barrier Permeability in Preclinical Models Using PET and SPECT

Vijayasree V. Giridharan, Tatiana Barichello, Sudhakar Selvaraj

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The blood–brain barrier (BBB) with tightest junction separates the systemic circulation and brain micro-environment to protect the brain from insults, such as infections. The integrity of BBB is preserved by multi-structural and functional components. Increasing evidence indicates that BBB is used as an important marker measured in variety of pathological condition with large permeability leaks, such as brain tumors and multiple sclerosis, to more subtle disruption such as vascular diseases, cognitive decline, and dementia. Several imaging modalities are available to study disruption of the BBB. In this chapter, we described the protocols for nuclear imaging studies such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) investigating BBB permeability in preclinical models.

Original languageEnglish (US)
Title of host publicationNeuromethods
PublisherHumana Press
Pages329-342
Number of pages14
DOIs
StatePublished - 2019

Publication series

NameNeuromethods
Volume142
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Keywords

  • Blood–brain barrier
  • Positron emission tomography
  • Single photon emission computed tomography

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

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