Molecular Events in the Natural History of Pancreatic Cancer

Leslie E. Oldfield, Ashton A. Connor, Steven Gallinger

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest epithelial malignancies. Improvements in our understanding of PDAC carcinogenesis will hopefully improve its detection, management, and outcomes, as has been achieved with other malignancies. Here we review the literature on the natural history of PDAC, including its cell of origin, the initiating somatic mutational events, pathways deranged in the mature tumor, its biological heterogeneity, and the relationship of the primary tumor with metastases. We also suggest areas for further research and highlight translatable findings that are beginning to make clinical inroads.

Original languageEnglish (US)
Pages (from-to)336-346
Number of pages11
JournalTrends in Cancer
Issue number5
StatePublished - May 2017


  • genomics
  • molecular biology
  • pancreatic cancer
  • review
  • transcriptomics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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