TY - JOUR
T1 - Molecular Evaluation of Endoplasmic Reticulum Homeostasis Meets Humoral Immunity
AU - van Anken, Eelco
AU - Bakunts, Anush
AU - Hu, Chih Chi Andrew
AU - Janssens, Sophie
AU - Sitia, Roberto
N1 - Funding Information:
The authors wish to thank Dr Andrea Orsi for introducing gloves in the artwork, and Drs Tomás Aragón, Ritwick Sawarkar, and Agnès Delaunay-Moisan for critical reading of the manuscript. E.v.A. acknowledges the Armenise-Harvard foundation, E.v.A. and R.S. acknowledge Fondazione AIRC per la Ricerca sul Cancro (MFAG 13584 to E.v.A.; IG 23285 to R.S.), and the Ministero dell'Università e Ricerca (PRIN XA5J5N) for financial support. A.B. acknowledges support from a Fondazione Centro San Raffaele Fellowship. C-C.A.H. acknowledges the National Institute of Health (R01 CA163910), and S.J. acknowledges an European Research Council Consolidator Grant (DCRIDDLE-819314), and the Research Foundation Flanders (FWO - G017521N; G063218N; G0G7318N) for financial support. The authors declare no competing interests
Funding Information:
The authors wish to thank Dr Andrea Orsi for introducing gloves in the artwork, and Drs Tomás Aragón, Ritwick Sawarkar, and Agnès Delaunay-Moisan for critical reading of the manuscript. E.v.A. acknowledges the Armenise-Harvard foundation , E.v.A. and R.S. acknowledge Fondazione AIRC per la Ricerca sul Cancro ( MFAG 13584 to E.v.A.; IG 23285 to R.S.), and the Ministero dell'Università e Ricerca ( PRIN XA5J5N ) for financial support. A.B. acknowledges support from a Fondazione Centro San Raffaele Fellowship. C-C.A.H. acknowledges the National Institute of Health ( R01 CA163910 ), and S.J. acknowledges an European Research Council Consolidator Grant ( DCRIDDLE-819314 ), and the Research Foundation Flanders (FWO - G017521N ; G063218N ; G0G7318N ) for financial support.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/7
Y1 - 2021/7
N2 - The biosynthesis of about one third of the human proteome, including membrane receptors and secreted proteins, occurs in the endoplasmic reticulum (ER). Conditions that perturb ER homeostasis activate the unfolded protein response (UPR). An ‘optimistic’ UPR output aims at restoring homeostasis by reinforcement of machineries that guarantee efficiency and fidelity of protein biogenesis in the ER. Yet, once the UPR ‘deems’ that ER homeostatic readjustment fails, it transitions to a ‘pessimistic’ output, which, depending on the cell type, will result in apoptosis. In this article, we discuss emerging concepts on how the UPR ‘evaluates’ ER stress, how the UPR is repurposed, in particular in B cells, and how UPR-driven counter-selection of cells undergoing homeostatic failure serves organismal homeostasis and humoral immunity.
AB - The biosynthesis of about one third of the human proteome, including membrane receptors and secreted proteins, occurs in the endoplasmic reticulum (ER). Conditions that perturb ER homeostasis activate the unfolded protein response (UPR). An ‘optimistic’ UPR output aims at restoring homeostasis by reinforcement of machineries that guarantee efficiency and fidelity of protein biogenesis in the ER. Yet, once the UPR ‘deems’ that ER homeostatic readjustment fails, it transitions to a ‘pessimistic’ output, which, depending on the cell type, will result in apoptosis. In this article, we discuss emerging concepts on how the UPR ‘evaluates’ ER stress, how the UPR is repurposed, in particular in B cells, and how UPR-driven counter-selection of cells undergoing homeostatic failure serves organismal homeostasis and humoral immunity.
KW - B cell development
KW - RIDD
KW - antibody production
KW - endoplasmic reticulum
KW - proteostasis
KW - unfolded protein response
UR - http://www.scopus.com/inward/record.url?scp=85102031957&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85102031957&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2021.02.004
DO - 10.1016/j.tcb.2021.02.004
M3 - Review article
C2 - 33685797
AN - SCOPUS:85102031957
VL - 31
SP - 529
EP - 541
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 7
ER -