We examined 215 Enterococcusfaecalis isolates and found that neither the two-component regulatory locus fsr (E. faecalis regulator) nor gelatinase production was more common in disease-associated isolates than in isolates colonizing healthy individuals (ca. 60 to 65%). The majority of gelatinase-negative isolates, including 14 endocarditis isolates (of 80 isolates tested), contained the previously described 23.9-kb deletion and lacked fsrA and fsrB. While these findings indicate that neitherfsr nor gelatinase is required for E. faecalis to cause infection, this study did not address whetherfsr or gelatinase affects the severity of disease, as it does in animal models.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Clinical Microbiology|
|State||Published - May 2004|
ASJC Scopus subject areas
- Microbiology (medical)