TY - JOUR
T1 - Molecular engineering of poly(HEMA-co-PEGMA)-based hydrogels
T2 - Role of minor AEMA and DMAEMA inclusion
AU - Bhat, Ankita
AU - Smith, Blake
AU - Dinu, Cerasela Zoica
AU - Guiseppi-Elie, Anthony
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/5
Y1 - 2019/5
N2 - Hydrogel membranes of in-dwelling pH-responsive devices are of interest for the development of biomedical sensors that must measure small changes in pH associated with tissue acidosis. Poly(2-hydroxyethyl methacrylate)-based hydrogels possessing minor amounts of the cationogenic N-(2-aminoethyl) methacrylamide (AEMA) (4 mol%) or a tertiary amine moiety, N,N-(2-dimethylamino)ethyl methacrylamide (DMAEMA) (4 mol%) or AEMA-DMAEMA (2 mol% each) were UV cross-linked with 1 mol% tetra(ethylene glycol) diacrylate (TEGDA) and the degree of hydration, free and bound water distribution, glass transition temperature, elastic modulus, membrane resistance and protein adsorption were studied. Correlation analysis reveals that each of these biotechnical properties is strongly anti-correlated with total hydration (−0.92) and that the bound water content dominates this anti-correlation (~−0.83). However, free water shows a direct, though only weak correlation with these properties (~+0.5). Thus, minor changes in the hydrogel composition (~4 mol%) can significantly influence biomaterials properties and may be useful in tailoring hydrogel properties for application in biosensors and engineered tissue scaffolds.
AB - Hydrogel membranes of in-dwelling pH-responsive devices are of interest for the development of biomedical sensors that must measure small changes in pH associated with tissue acidosis. Poly(2-hydroxyethyl methacrylate)-based hydrogels possessing minor amounts of the cationogenic N-(2-aminoethyl) methacrylamide (AEMA) (4 mol%) or a tertiary amine moiety, N,N-(2-dimethylamino)ethyl methacrylamide (DMAEMA) (4 mol%) or AEMA-DMAEMA (2 mol% each) were UV cross-linked with 1 mol% tetra(ethylene glycol) diacrylate (TEGDA) and the degree of hydration, free and bound water distribution, glass transition temperature, elastic modulus, membrane resistance and protein adsorption were studied. Correlation analysis reveals that each of these biotechnical properties is strongly anti-correlated with total hydration (−0.92) and that the bound water content dominates this anti-correlation (~−0.83). However, free water shows a direct, though only weak correlation with these properties (~+0.5). Thus, minor changes in the hydrogel composition (~4 mol%) can significantly influence biomaterials properties and may be useful in tailoring hydrogel properties for application in biosensors and engineered tissue scaffolds.
KW - Impedance
KW - Protein adsorption
KW - Water-distribution
KW - p(HEMA)-based hydrogels
KW - pH-sensitivity
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U2 - 10.1016/j.msec.2018.12.083
DO - 10.1016/j.msec.2018.12.083
M3 - Article
C2 - 30813095
AN - SCOPUS:85059343135
VL - 98
SP - 89
EP - 100
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
SN - 0928-4931
ER -