Molecular dynamics simulation study reveals potential substrate entry path into γ-secretase/presenilin-1

Keyphrases

• Presenilin 100%
• Secretase 100%
• Molecular Dynamics Simulation Study 100%
• Substrate Entry 100%
• Alzheimer's Disease 33%
• Lipid Bilayer 33%
• Catalytic Residues 33%
• Conformation Change 16%
• Palmitoyl-CoA 16%
• Hydrolysis 16%
• Active Sites 16%
• Cancer Types 16%
• Membrane Phospholipids 16%
• Amyloid Precursor Protein 16%
• Catalytic Subunit 16%
• Molecular Dynamics Simulation 16%
• Direct Interaction 16%
• Dynamic Behavior 16%
• Lipid Molecules 16%
• Intramembrane Proteolysis 16%
• Homology Modeling 16%
• Phosphoethanolamine 16%
• Intermediate State 16%
• Molecular Simulation Study 16%
• Open Access Movement 16%
• Hydrolysis Process 16%
• Strategy Development 16%
• Penetration Pathways 16%

Biochemistry, Genetics and Molecular Biology

• Presenilin 100%
• Secretase 100%
• Enzymatic Hydrolysis 33%
• Lipid Bilayer 33%
• Lipid 16%
• Conformation 16%
• Active Site 16%
• Phospholipid 16%
• Proteolysis 16%
• Amyloid Precursor Protein 16%
• Notch 16%