Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping

Tominaga Shin-ichi Tominaga; Nancy A. Jenkins; Debra J. Gilbert; Neal G. Copeland; Tsunao Tetsuka

doi:10.1016/0167-4781(91)90029-L

Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping

Tominaga Shin-ichi Tominaga, Nancy A. Jenkins, Debra J. Gilbert, Neal G. Copeland, Tsunao Tetsuka

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Abstract

The genomic locus of the murine ST2 gene was isolated based on homology with a murine ST2 complementary DNA sequence and its complete nucleotide sequence was determined. The locus is composed of eight exons and seven introns and is approx. 9 kilobase pairs in size. Two Sp1 binding sites are present in the 5′ flanking region. The murine ST2 gene, which was expressed only in the growth-stimulated BALB/c-3T3 cells, was mapped to mouse chromosome one, very tightly linked to the interleukin 1 receptor-type 1 locus.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	BBA - Gene Structure and Expression
Volume	1090
Issue number	1
DOIs	https://doi.org/10.1016/0167-4781(91)90029-L
State	Published - Aug 27 1991

Keywords

Cell cycle
Cell growth
Immunoglobulin superfamily
Interleukin 1 receptor

ASJC Scopus subject areas

Structural Biology
Genetics
Biophysics
Biochemistry

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abstract = "The genomic locus of the murine ST2 gene was isolated based on homology with a murine ST2 complementary DNA sequence and its complete nucleotide sequence was determined. The locus is composed of eight exons and seven introns and is approx. 9 kilobase pairs in size. Two Sp1 binding sites are present in the 5′ flanking region. The murine ST2 gene, which was expressed only in the growth-stimulated BALB/c-3T3 cells, was mapped to mouse chromosome one, very tightly linked to the interleukin 1 receptor-type 1 locus.",

keywords = "Cell cycle, Cell growth, Immunoglobulin superfamily, Interleukin 1 receptor",

author = "{Shin-ichi Tominaga}, Tominaga and Jenkins, {Nancy A.} and Gilbert, {Debra J.} and Copeland, {Neal G.} and Tsunao Tetsuka",

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AU - Shin-ichi Tominaga, Tominaga

AU - Jenkins, Nancy A.

AU - Gilbert, Debra J.

AU - Copeland, Neal G.

AU - Tetsuka, Tsunao

PY - 1991/8/27

Y1 - 1991/8/27

N2 - The genomic locus of the murine ST2 gene was isolated based on homology with a murine ST2 complementary DNA sequence and its complete nucleotide sequence was determined. The locus is composed of eight exons and seven introns and is approx. 9 kilobase pairs in size. Two Sp1 binding sites are present in the 5′ flanking region. The murine ST2 gene, which was expressed only in the growth-stimulated BALB/c-3T3 cells, was mapped to mouse chromosome one, very tightly linked to the interleukin 1 receptor-type 1 locus.

AB - The genomic locus of the murine ST2 gene was isolated based on homology with a murine ST2 complementary DNA sequence and its complete nucleotide sequence was determined. The locus is composed of eight exons and seven introns and is approx. 9 kilobase pairs in size. Two Sp1 binding sites are present in the 5′ flanking region. The murine ST2 gene, which was expressed only in the growth-stimulated BALB/c-3T3 cells, was mapped to mouse chromosome one, very tightly linked to the interleukin 1 receptor-type 1 locus.

KW - Cell cycle

KW - Cell growth

KW - Immunoglobulin superfamily

KW - Interleukin 1 receptor

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Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping

Abstract

Keywords

ASJC Scopus subject areas

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