Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping

Tominaga Shin-ichi Tominaga, Nancy A. Jenkins, Debra J. Gilbert, Neal G. Copeland, Tsunao Tetsuka

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

The genomic locus of the murine ST2 gene was isolated based on homology with a murine ST2 complementary DNA sequence and its complete nucleotide sequence was determined. The locus is composed of eight exons and seven introns and is approx. 9 kilobase pairs in size. Two Sp1 binding sites are present in the 5′ flanking region. The murine ST2 gene, which was expressed only in the growth-stimulated BALB/c-3T3 cells, was mapped to mouse chromosome one, very tightly linked to the interleukin 1 receptor-type 1 locus.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalBBA - Gene Structure and Expression
Volume1090
Issue number1
DOIs
StatePublished - Aug 27 1991

Keywords

  • Cell cycle
  • Cell growth
  • Immunoglobulin superfamily
  • Interleukin 1 receptor

ASJC Scopus subject areas

  • Structural Biology
  • Genetics
  • Biophysics
  • Biochemistry

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