Molecular Cloning of Mouse Collectin Liver 1

Takao Kawai, Yasuhiko Suzuki, Souji Eda, Tetsuo Kase, Katsuki Ohtani, Yoshinori Sakai, Hiroyuki Keshi, Atsushi Fukuoh, Takashi Sakamoto, Masami Nozaki, Neal G. Copeland, Nancy A. Jenkins, Nobutaka Wakamiya

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Collectins are members of the superfamily of vertebrate C-type lectins that contain a collagen-like region, and are involved in first-line host defense. We earlier cloned and characterized a new kind of collectin, collectin liver 1 (CL-L1). In this study, we isolated the mouse homologue of CL-L1 encoding 277 amino acid residues; its deduced protein sequence was 88% identical with human CL-L1. Mouse CL-L1 mRNA was expressed mainly in the liver and stomach, but was found also in muscles, testes, intestines, and embryos. In mouse embryos, the level of CL-L1 mRNA gradually increased with embryonic age. In 16-day-old mouse embryos, CL-L1 mRNA was expressed in the liver, amnion, and visceral yolk sac. The mouse CL-L1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q. CL-L1 was a highly conserved protein in mammals, birds, and fish.

Original languageEnglish (US)
Pages (from-to)2134-2145
Number of pages12
JournalBioscience, Biotechnology and Biochemistry
Volume66
Issue number10
DOIs
StatePublished - Jan 1 2002

Keywords

  • cDNA
  • Chromosome
  • Collectin
  • Collectin liver 1
  • Mouse

ASJC Scopus subject areas

  • Food Science
  • Applied Microbiology and Biotechnology
  • Chemistry (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Bioengineering

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