Molecular Cloning of Mouse Collectin Liver 1

Takao Kawai; Yasuhiko Suzuki; Souji Eda; Tetsuo Kase; Katsuki Ohtani; Yoshinori Sakai; Hiroyuki Keshi; Atsushi Fukuoh; Takashi Sakamoto; Masami Nozaki; Neal G. Copeland; Nancy A. Jenkins; Nobutaka Wakamiya

doi:10.1271/bbb.66.2134

Molecular Cloning of Mouse Collectin Liver 1

Takao Kawai, Yasuhiko Suzuki, Souji Eda, Tetsuo Kase, Katsuki Ohtani, Yoshinori Sakai, Hiroyuki Keshi, Atsushi Fukuoh, Takashi Sakamoto, Masami Nozaki, Neal G. Copeland, Nancy A. Jenkins, Nobutaka Wakamiya

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Collectins are members of the superfamily of vertebrate C-type lectins that contain a collagen-like region, and are involved in first-line host defense. We earlier cloned and characterized a new kind of collectin, collectin liver 1 (CL-L1). In this study, we isolated the mouse homologue of CL-L1 encoding 277 amino acid residues; its deduced protein sequence was 88% identical with human CL-L1. Mouse CL-L1 mRNA was expressed mainly in the liver and stomach, but was found also in muscles, testes, intestines, and embryos. In mouse embryos, the level of CL-L1 mRNA gradually increased with embryonic age. In 16-day-old mouse embryos, CL-L1 mRNA was expressed in the liver, amnion, and visceral yolk sac. The mouse CL-L1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q. CL-L1 was a highly conserved protein in mammals, birds, and fish.

Original language	English (US)
Pages (from-to)	2134-2145
Number of pages	12
Journal	Bioscience, Biotechnology and Biochemistry
Volume	66
Issue number	10
DOIs	https://doi.org/10.1271/bbb.66.2134
State	Published - Jan 1 2002

Keywords

cDNA
Chromosome
Collectin
Collectin liver 1
Mouse

ASJC Scopus subject areas

Food Science
Applied Microbiology and Biotechnology
Chemistry (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)
Biochemistry
Biotechnology
Bioengineering

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title = "Molecular Cloning of Mouse Collectin Liver 1",

abstract = "Collectins are members of the superfamily of vertebrate C-type lectins that contain a collagen-like region, and are involved in first-line host defense. We earlier cloned and characterized a new kind of collectin, collectin liver 1 (CL-L1). In this study, we isolated the mouse homologue of CL-L1 encoding 277 amino acid residues; its deduced protein sequence was 88% identical with human CL-L1. Mouse CL-L1 mRNA was expressed mainly in the liver and stomach, but was found also in muscles, testes, intestines, and embryos. In mouse embryos, the level of CL-L1 mRNA gradually increased with embryonic age. In 16-day-old mouse embryos, CL-L1 mRNA was expressed in the liver, amnion, and visceral yolk sac. The mouse CL-L1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q. CL-L1 was a highly conserved protein in mammals, birds, and fish.",

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AU - Sakai, Yoshinori

AU - Keshi, Hiroyuki

AU - Fukuoh, Atsushi

AU - Sakamoto, Takashi

AU - Nozaki, Masami

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Wakamiya, Nobutaka

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N2 - Collectins are members of the superfamily of vertebrate C-type lectins that contain a collagen-like region, and are involved in first-line host defense. We earlier cloned and characterized a new kind of collectin, collectin liver 1 (CL-L1). In this study, we isolated the mouse homologue of CL-L1 encoding 277 amino acid residues; its deduced protein sequence was 88% identical with human CL-L1. Mouse CL-L1 mRNA was expressed mainly in the liver and stomach, but was found also in muscles, testes, intestines, and embryos. In mouse embryos, the level of CL-L1 mRNA gradually increased with embryonic age. In 16-day-old mouse embryos, CL-L1 mRNA was expressed in the liver, amnion, and visceral yolk sac. The mouse CL-L1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q. CL-L1 was a highly conserved protein in mammals, birds, and fish.

AB - Collectins are members of the superfamily of vertebrate C-type lectins that contain a collagen-like region, and are involved in first-line host defense. We earlier cloned and characterized a new kind of collectin, collectin liver 1 (CL-L1). In this study, we isolated the mouse homologue of CL-L1 encoding 277 amino acid residues; its deduced protein sequence was 88% identical with human CL-L1. Mouse CL-L1 mRNA was expressed mainly in the liver and stomach, but was found also in muscles, testes, intestines, and embryos. In mouse embryos, the level of CL-L1 mRNA gradually increased with embryonic age. In 16-day-old mouse embryos, CL-L1 mRNA was expressed in the liver, amnion, and visceral yolk sac. The mouse CL-L1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q. CL-L1 was a highly conserved protein in mammals, birds, and fish.

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KW - Mouse

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Molecular Cloning of Mouse Collectin Liver 1

Abstract

Keywords

ASJC Scopus subject areas

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