Molecular Cloning of Mouse Collectin Liver 1

Takao Kawai; Yasuhiko Suzuki; Souji Eda; Tetsuo Kase; Katsuki Ohtani; Yoshinori Sakai; Hiroyuki Keshi; Atsushi Fukuoh; Takashi Sakamoto; Masami Nozaki; Neal G. Copeland; Nancy A. Jenkins; Nobutaka Wakamiya

doi:10.1271/bbb.66.2134

Molecular Cloning of Mouse Collectin Liver 1

Takao Kawai, Yasuhiko Suzuki, Souji Eda, Tetsuo Kase, Katsuki Ohtani, Yoshinori Sakai, Hiroyuki Keshi, Atsushi Fukuoh, Takashi Sakamoto, Masami Nozaki, Neal G. Copeland, Nancy A. Jenkins, Nobutaka Wakamiya

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Collectins are members of the superfamily of vertebrate C-type lectins that contain a collagen-like region, and are involved in first-line host defense. We earlier cloned and characterized a new kind of collectin, collectin liver 1 (CL-L1). In this study, we isolated the mouse homologue of CL-L1 encoding 277 amino acid residues; its deduced protein sequence was 88% identical with human CL-L1. Mouse CL-L1 mRNA was expressed mainly in the liver and stomach, but was found also in muscles, testes, intestines, and embryos. In mouse embryos, the level of CL-L1 mRNA gradually increased with embryonic age. In 16-day-old mouse embryos, CL-L1 mRNA was expressed in the liver, amnion, and visceral yolk sac. The mouse CL-L1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q. CL-L1 was a highly conserved protein in mammals, birds, and fish.

Original language	English (US)
Pages (from-to)	2134-2145
Number of pages	12
Journal	Bioscience, Biotechnology and Biochemistry
Volume	66
Issue number	10
DOIs	https://doi.org/10.1271/bbb.66.2134
State	Published - Jan 1 2002

Keywords

cDNA
Chromosome
Collectin
Collectin liver 1
Mouse

ASJC Scopus subject areas

Food Science
Applied Microbiology and Biotechnology
Chemistry (miscellaneous)
General Biochemistry, Genetics and Molecular Biology
Biochemistry
Biotechnology
Bioengineering

Access to Document

10.1271/bbb.66.2134

Cite this

@article{c4016a63f25347f593355edbfcbc708b,

title = "Molecular Cloning of Mouse Collectin Liver 1",

abstract = "Collectins are members of the superfamily of vertebrate C-type lectins that contain a collagen-like region, and are involved in first-line host defense. We earlier cloned and characterized a new kind of collectin, collectin liver 1 (CL-L1). In this study, we isolated the mouse homologue of CL-L1 encoding 277 amino acid residues; its deduced protein sequence was 88% identical with human CL-L1. Mouse CL-L1 mRNA was expressed mainly in the liver and stomach, but was found also in muscles, testes, intestines, and embryos. In mouse embryos, the level of CL-L1 mRNA gradually increased with embryonic age. In 16-day-old mouse embryos, CL-L1 mRNA was expressed in the liver, amnion, and visceral yolk sac. The mouse CL-L1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q. CL-L1 was a highly conserved protein in mammals, birds, and fish.",

keywords = "cDNA, Chromosome, Collectin, Collectin liver 1, Mouse",

author = "Takao Kawai and Yasuhiko Suzuki and Souji Eda and Tetsuo Kase and Katsuki Ohtani and Yoshinori Sakai and Hiroyuki Keshi and Atsushi Fukuoh and Takashi Sakamoto and Masami Nozaki and Copeland, {Neal G.} and Jenkins, {Nancy A.} and Nobutaka Wakamiya",

year = "2002",

month = jan,

day = "1",

doi = "10.1271/bbb.66.2134",

language = "English (US)",

volume = "66",

pages = "2134--2145",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Oxford University Press",

number = "10",

}

TY - JOUR

T1 - Molecular Cloning of Mouse Collectin Liver 1

AU - Kawai, Takao

AU - Suzuki, Yasuhiko

AU - Eda, Souji

AU - Kase, Tetsuo

AU - Ohtani, Katsuki

AU - Sakai, Yoshinori

AU - Keshi, Hiroyuki

AU - Fukuoh, Atsushi

AU - Sakamoto, Takashi

AU - Nozaki, Masami

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Wakamiya, Nobutaka

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Collectins are members of the superfamily of vertebrate C-type lectins that contain a collagen-like region, and are involved in first-line host defense. We earlier cloned and characterized a new kind of collectin, collectin liver 1 (CL-L1). In this study, we isolated the mouse homologue of CL-L1 encoding 277 amino acid residues; its deduced protein sequence was 88% identical with human CL-L1. Mouse CL-L1 mRNA was expressed mainly in the liver and stomach, but was found also in muscles, testes, intestines, and embryos. In mouse embryos, the level of CL-L1 mRNA gradually increased with embryonic age. In 16-day-old mouse embryos, CL-L1 mRNA was expressed in the liver, amnion, and visceral yolk sac. The mouse CL-L1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q. CL-L1 was a highly conserved protein in mammals, birds, and fish.

AB - Collectins are members of the superfamily of vertebrate C-type lectins that contain a collagen-like region, and are involved in first-line host defense. We earlier cloned and characterized a new kind of collectin, collectin liver 1 (CL-L1). In this study, we isolated the mouse homologue of CL-L1 encoding 277 amino acid residues; its deduced protein sequence was 88% identical with human CL-L1. Mouse CL-L1 mRNA was expressed mainly in the liver and stomach, but was found also in muscles, testes, intestines, and embryos. In mouse embryos, the level of CL-L1 mRNA gradually increased with embryonic age. In 16-day-old mouse embryos, CL-L1 mRNA was expressed in the liver, amnion, and visceral yolk sac. The mouse CL-L1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q. CL-L1 was a highly conserved protein in mammals, birds, and fish.

KW - cDNA

KW - Chromosome

KW - Collectin

KW - Collectin liver 1

KW - Mouse

UR - http://www.scopus.com/inward/record.url?scp=4544249611&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4544249611&partnerID=8YFLogxK

U2 - 10.1271/bbb.66.2134

DO - 10.1271/bbb.66.2134

M3 - Article

C2 - 12450124

AN - SCOPUS:4544249611

SN - 0916-8451

VL - 66

SP - 2134

EP - 2145

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 10

ER -

Molecular Cloning of Mouse Collectin Liver 1

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this