Molecular cloning and characterization of MHC class I- and II-restricted tumor antigens recognized by T cells

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4 Scopus citations

Abstract

T cells play a central role in cancer immunosurveillance, autoimmune, and infectious diseases. Identification of MHC class I- and II-restricted T cell peptides is a critical step for the development of effective vaccines against cancer and infectious diseases. This unit describes a cDNA expression system and a genetic targeting expression system for the cloning of genes encoding forMHC class I- and II-restricted antigens recognized by antigen-specific CD8+ and CD4+ T cells.

Original languageEnglish (US)
JournalCurrent Protocols in Immunology
Issue numberSUPPL. 84
DOIs
StatePublished - Mar 12 2009

Keywords

  • Cancer vaccines
  • CD4 T cells
  • cDNA library
  • Immunotherapy
  • MHC class II
  • T helper peptides
  • Targeting expression
  • Tumor antigens

ASJC Scopus subject areas

  • Immunology

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