Abstract
New discoveries are expanding our knowledge of mechanisms involved in amyotrophic lateral sclerosis (ALS) pathogenesis. Some recent advances in our understanding of motoneuron death in familial ALS (fALS) and sporadic ALS (sALS) are reviewed, with emphasis on molecular similarities that may further unite these phenotypically linked diseases.
Original language | English (US) |
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Pages (from-to) | 133-145 |
Number of pages | 13 |
Journal | Annual Review of Medicine |
Volume | 46 |
DOIs | |
State | Published - May 3 1995 |
Keywords
- Autoimmune motoneuron injury
- Calcium channel
- Excitotoxicity
- Oxidative injury
- Superoxide dismutase deficiency
ASJC Scopus subject areas
- Cell Biology
- Medicine(all)