Molecular approaches to amyotrophic lateral sclerosis

R. Glenn Smith; Stanley H. Appel

doi:10.1146/annurev.med.46.1.133

Molecular approaches to amyotrophic lateral sclerosis

R. Glenn Smith, Stanley H. Appel

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

New discoveries are expanding our knowledge of mechanisms involved in amyotrophic lateral sclerosis (ALS) pathogenesis. Some recent advances in our understanding of motoneuron death in familial ALS (fALS) and sporadic ALS (sALS) are reviewed, with emphasis on molecular similarities that may further unite these phenotypically linked diseases.

Original language	English (US)
Pages (from-to)	133-145
Number of pages	13
Journal	Annual Review of Medicine
Volume	46
DOIs	https://doi.org/10.1146/annurev.med.46.1.133
State	Published - May 3 1995

Keywords

Autoimmune motoneuron injury
Calcium channel
Excitotoxicity
Oxidative injury
Superoxide dismutase deficiency

ASJC Scopus subject areas

Cell Biology
Medicine(all)

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10.1146/annurev.med.46.1.133

Cite this

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title = "Molecular approaches to amyotrophic lateral sclerosis",

abstract = "New discoveries are expanding our knowledge of mechanisms involved in amyotrophic lateral sclerosis (ALS) pathogenesis. Some recent advances in our understanding of motoneuron death in familial ALS (fALS) and sporadic ALS (sALS) are reviewed, with emphasis on molecular similarities that may further unite these phenotypically linked diseases.",

keywords = "Autoimmune motoneuron injury, Calcium channel, Excitotoxicity, Oxidative injury, Superoxide dismutase deficiency",

author = "Smith, {R. Glenn} and Appel, {Stanley H.}",

year = "1995",

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doi = "10.1146/annurev.med.46.1.133",

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AU - Appel, Stanley H.

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AB - New discoveries are expanding our knowledge of mechanisms involved in amyotrophic lateral sclerosis (ALS) pathogenesis. Some recent advances in our understanding of motoneuron death in familial ALS (fALS) and sporadic ALS (sALS) are reviewed, with emphasis on molecular similarities that may further unite these phenotypically linked diseases.

KW - Autoimmune motoneuron injury

KW - Calcium channel

KW - Excitotoxicity

KW - Oxidative injury

KW - Superoxide dismutase deficiency

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JO - Annual Review of Medicine

JF - Annual Review of Medicine

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Molecular approaches to amyotrophic lateral sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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