Molecular approaches to amyotrophic lateral sclerosis

R. Glenn Smith, Stanley H. Appel

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


New discoveries are expanding our knowledge of mechanisms involved in amyotrophic lateral sclerosis (ALS) pathogenesis. Some recent advances in our understanding of motoneuron death in familial ALS (fALS) and sporadic ALS (sALS) are reviewed, with emphasis on molecular similarities that may further unite these phenotypically linked diseases.

Original languageEnglish (US)
Pages (from-to)133-145
Number of pages13
JournalAnnual Review of Medicine
StatePublished - May 3 1995


  • Autoimmune motoneuron injury
  • Calcium channel
  • Excitotoxicity
  • Oxidative injury
  • Superoxide dismutase deficiency

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)


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