Modulatory effect of human plasma on the internal nanostructure and size characteristics of liquid-crystalline nanocarriers

Intan Diana Mat Azmi, Linping Wu, Peter Popp Wibroe, Christa Nilsson, Jesper Østergaard, Stefan Stürup, Bente Gammelgaard, Arto Urtti, Seyed Moein Moghimi, Anan Yaghmur

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The inverted-type liquid-crystalline dispersions comprising cubosomes and hexosomes hold much potential for drug solubilization and site-specific targeting on intravenous administration. Limited information, however, is available on the influence of plasma components on nanostructural and morphological features of cubosome and hexosome dispersions, which may modulate their stability in the blood and their overall biological performance. Through an integrated approach involving SAXS, cryo-TEM, and nanoparticle tracking analysis (NTA) we have studied the time-dependent effect of human plasma (and the plasma complement system) on the integrity of the internal nanostructure, morphology, and fluctuation in size distribution of phytantriol (PHYT)-based nonlamellar crystalline dispersions. The results indicate that in the presence of plasma the internal nanostructure undergoes a transition from the biphasic phase (a bicontinuous cubic phase with symmetry Pn3m coexisting with an inverted-type hexagonal (H2) phase) to a neat hexagonal (H2) phase, which decreases the median particle size. These observations were independent of a direct effect by serum albumin and dispersion-mediated complement activation. The implication of these observations in relation to soft nanocarrier design for intravenous drug delivery is discussed.

Original languageEnglish (US)
Pages (from-to)5042-5049
Number of pages8
JournalLangmuir
Volume31
Issue number18
DOIs
StatePublished - May 12 2015

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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