Modulation of rat hepatic microsomal testosterone hydroxylases by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and related toxic isostereomers

B. Keys, M. Hlavinka, G. Mason, S. Safe

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The effects of several toxic halogenated aryl hydrocarbons including 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, 2, 3, 7, 8-tetrachlorodibenzofuran, 2, 3, 4, 7, 8-pentachlorodibenzofuran, 3, 3', 4, 4'-tetrabromobiphenyl, 3, 3', 4, 4'5-pentachlorobiphenyl, and 3, 3', 4, 4'-tetrachloroazobenzene on hepatic microsomal testosterone hydroxylases were determined in the immature male rat. All of these compounds induced hepatic testosterone 7α-hydroxylase and inhibited testosterone 6β-, 16α-, 16β-, and 2α-hydroxylases and androstenedione formation. It was observed that there was a good correlation between the increase in testosterone 7α-hydroxylase by the halogenated hydrocarbons and their ability to cause body weight loss in the exposed rats. Comparable linear correlations were observed between toxicity and the decreased activities of other testosterone hydroxylases. The role of altered testosterone metabolism in the toxicity of halogenated aryl hydrocarbons is unknown.

Original languageEnglish (US)
Pages (from-to)1537-1542
Number of pages6
JournalCanadian Journal of Physiology and Pharmacology
Volume63
Issue number12
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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