Modulation of postjunctional α-adrenergic responsiveness by local changes in temperature

P. M. Vanhoutte; John P. Cooke; L. E. Lindblad; J. T. Shepherd; N. A. Flavahan

Modulation of postjunctional α-adrenergic responsiveness by local changes in temperature

P. M. Vanhoutte, John P. Cooke, L. E. Lindblad, J. T. Shepherd, N. A. Flavahan

Research output: Contribution to journal › Article › peer-review

Abstract

1. In canine cutaneous veins, local moderate warming (37°-41°C) augments the responsiveness to postjunctional α₁-adrenergic stimulation but depresses that to postjunctional α₂-adrenergic activation. Moderate cooling (37° C-24°C) has the opposite effect. 2. The effects of warming and cooling on α₁-adrenergic responses are buffered by a large receptor reserve, allowing for the predominance of alterations in α₂-adrenergic responsiveness.

Original language	English (US)
Journal	Clinical Science
Volume	68
Issue number	SUPPL. 10
State	Published - May 8 1985

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Modulation of postjunctional α-adrenergic responsiveness by local changes in temperature",

abstract = "1. In canine cutaneous veins, local moderate warming (37°-41°C) augments the responsiveness to postjunctional α1-adrenergic stimulation but depresses that to postjunctional α2-adrenergic activation. Moderate cooling (37° C-24°C) has the opposite effect. 2. The effects of warming and cooling on α1-adrenergic responses are buffered by a large receptor reserve, allowing for the predominance of alterations in α2-adrenergic responsiveness.",

author = "Vanhoutte, \{P. M.\} and Cooke, \{John P.\} and Lindblad, \{L. E.\} and Shepherd, \{J. T.\} and Flavahan, \{N. A.\}",

year = "1985",

month = may,

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language = "English (US)",

volume = "68",

journal = "Clinical Science",

issn = "0143-5221",

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AU - Vanhoutte, P. M.

AU - Cooke, John P.

AU - Lindblad, L. E.

AU - Shepherd, J. T.

AU - Flavahan, N. A.

PY - 1985/5/8

Y1 - 1985/5/8

N2 - 1. In canine cutaneous veins, local moderate warming (37°-41°C) augments the responsiveness to postjunctional α1-adrenergic stimulation but depresses that to postjunctional α2-adrenergic activation. Moderate cooling (37° C-24°C) has the opposite effect. 2. The effects of warming and cooling on α1-adrenergic responses are buffered by a large receptor reserve, allowing for the predominance of alterations in α2-adrenergic responsiveness.

AB - 1. In canine cutaneous veins, local moderate warming (37°-41°C) augments the responsiveness to postjunctional α1-adrenergic stimulation but depresses that to postjunctional α2-adrenergic activation. Moderate cooling (37° C-24°C) has the opposite effect. 2. The effects of warming and cooling on α1-adrenergic responses are buffered by a large receptor reserve, allowing for the predominance of alterations in α2-adrenergic responsiveness.

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M3 - Article

C2 - 2857606

AN - SCOPUS:0021911566

SN - 0143-5221

VL - 68

JO - Clinical Science

JF - Clinical Science

IS - SUPPL. 10

ER -

Modulation of postjunctional α-adrenergic responsiveness by local changes in temperature

Abstract

ASJC Scopus subject areas

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