Modulation of postjunctional α-adrenergic responsiveness by local changes in temperature

P. M. Vanhoutte, John P. Cooke, L. E. Lindblad, J. T. Shepherd, N. A. Flavahan

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

1. In canine cutaneous veins, local moderate warming (37°-41°C) augments the responsiveness to postjunctional α1-adrenergic stimulation but depresses that to postjunctional α2-adrenergic activation. Moderate cooling (37° C-24°C) has the opposite effect. 2. The effects of warming and cooling on α1-adrenergic responses are buffered by a large receptor reserve, allowing for the predominance of alterations in α2-adrenergic responsiveness.

Original languageEnglish (US)
JournalClinical Science
Volume68
Issue numberSUPPL. 10
StatePublished - May 8 1985

ASJC Scopus subject areas

  • Medicine(all)

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