Abstract

Graft loss to rejection remains a key impediment to transplant success, which limits the therapeutic potential of this procedure. Though adaptive immune cells are critical in rejection, recent studies have demonstrated the importance of innate immune cells in dictating transplant outcomes (rejection or survival), highlighting the necessity in therapeutically targeting innate immune cells in the induction of tolerance to organ transplants. However, there are many challenges facing the field, as innate immune system consists of diverse cell types, molecular sensors, and soluble mediators that are different from those in the adaptive system. Also, some innate immune cells mediate graft injury, while others promote transplant survival, making therapeutic targeting of innate immune cells a challenging task. In this chapter, key elements in the innate immune system, their responses to organ transplants, as well as the challenges and opportunities in targeting those elements in favor of transplant survival are reviewed.

Original languageEnglish (US)
Title of host publicationThe Immune Response to Implanted Materials and Devices
Subtitle of host publicationThe Impact of the Immune System on the Success of an Implant
EditorsBruna Corradetti
PublisherSpringer International Publishing
Pages125-150
Number of pages26
ISBN (Electronic)9783319454337
ISBN (Print)9783319454313
DOIs
StatePublished - Jan 1 2016

Keywords

  • Complement
  • Dendritic cells
  • Innate immunity
  • Ischemia-reperfusion injury
  • Macrophages
  • Natural killer cells
  • Toll-like receptors (TLRs)
  • Transplant rejection
  • Transplant tolerance

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Immunology and Microbiology(all)

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