@article{3546f9ba88864784af798ac190bb977d,
title = "Modulating the tumor microenvironment with new therapeutic nanoparticles: A promising paradigm for tumor treatment",
abstract = "To better make nanomedicine entering the clinic, developing new rationally designed nanotherapeutics with a deeper understanding of tumor biology is required. The tumor microenvironment is similar to the inflammatory response in a healing wound, the milieu of which promotes tumor cell invasion and metastasis. Successful targeting of the microenvironmental components with effective nanotherapeutics to modulate the tumor microvessels or restore the homeostatic mechanisms in the tumor stroma will offer new hope for cancer treatment. We here highlight the progress in constructing nanotherapeutics to target or modulate the tumor microenvironment. We discuss the factors necessary for nanomedicines to become a new paradigm in cancer therapy, including the selection of drugs and therapeutic targets, controllable synthesis, and tempo-spatial drug release.",
keywords = "drug delivery, nanotherapeutics, therapeutic targets, tumor microenvironment",
author = "Yinlong Zhang and Ho, {Shih Hsin} and Bozhao Li and Guangjun Nie and Suping Li",
note = "Funding Information: This work was supported by grants from the National Basic Research Plan of China (2018YFA0208900), the National Postdoctoral Program for Innovative Talents (BX20180083), Beijing Municipal Science and Technology Commission Preclinical Program (Z161100000116026), Beijing Nova Program Interdisciplinary Cooperation Project (Z181100006218136), Key Research Program of Frontier Sciences CAS (ZDBS‐LY‐SLH039), and Beijing Municipal Natural Science Foundation (7182126). Funding Information: This work was supported by grants from the National Basic Research Plan of China (2018YFA0208900), the National Postdoctoral Program for Innovative Talents (BX20180083), Beijing Municipal Science and Technology Commission Preclinical Program (Z161100000116026), Beijing Nova Program Interdisciplinary Cooperation Project (Z181100006218136), Key Research Program of Frontier Sciences CAS (ZDBS-LY-SLH039), and Beijing Municipal Natural Science Foundation (7182126). Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = may,
day = "1",
doi = "10.1002/med.21644",
language = "English (US)",
volume = "40",
pages = "1084--1102",
journal = "Medicinal Research Reviews",
issn = "0198-6325",
publisher = "Wiley",
number = "3",
}