TY - JOUR
T1 - Modular Assembly of Red Blood Cell Superstructures from Metal–Organic Framework Nanoparticle-Based Building Blocks
AU - Guo, Jimin
AU - Yu, Yunlong
AU - Zhu, Wei
AU - Serda, Rita E.
AU - Franco, Stefan
AU - Wang, Lu
AU - Lei, Qi
AU - Agola, Jacob Ongudi
AU - Noureddine, Achraf
AU - Ploetz, Evelyn
AU - Wuttke, Stefan
AU - Brinker, C. Jeffrey
N1 - Funding Information:
C.J.B. acknowledge support from the University of New Mexico Center for Micro‐Engineered Materials. C.J.B. and R.E.S. acknowledge support from NIH RO1 (FP0003261 and CA226537). C.J.B. acknowledges support by the Sandia National Laboratory Laboratory‐Directed Research and Development Program and support from the Department of Energy Office of Science, Division of Materials Science and Engineering. This work was supported, in part, by the National Science Foundation (NSF) under Cooperative Agreement No. EEC‐1647722. R.E.S. acknowledges use of the UNM Animal Models and Microscopy facilities, supported by UNM Comprehensive Cancer Center NCI grant 2P30 CA118100‐11. W.Z. acknowledges the financial support from National Natural Science Foundation of China (21972047), Guangdong Provincial Pearl River Talents Program (2019QN01Y314), and the Program for Guangdong Introducing Innovative and Entrepreneurial Teams (2019ZT08Y318). E.P. acknowledges funding by the Deutsche Forschungsgemeinschaft (DFG) project PL 696/4‐1. S.W. acknowledges funding from the Basque Government Industry Department under the ELKARTEK and HAZITEK programs.
Funding Information:
J.G. and Y.Y. contributed equally to this work. C.J.B. acknowledge support from the University of New Mexico Center for Micro-Engineered Materials. C.J.B. and R.E.S. acknowledge support from NIH RO1 (FP0003261 and CA226537). C.J.B. acknowledges support by the Sandia National Laboratory Laboratory-Directed Research and Development Program and support from the Department of Energy Office of Science, Division of Materials Science and Engineering. This work was supported, in part, by the National Science Foundation (NSF) under Cooperative Agreement No. EEC-1647722. R.E.S. acknowledges use of the UNM Animal Models and Microscopy facilities, supported by UNM Comprehensive Cancer Center NCI grant 2P30 CA118100-11. W.Z. acknowledges the financial support from National Natural Science Foundation of China (21972047), Guangdong Provincial Pearl River Talents Program (2019QN01Y314), and the Program for Guangdong Introducing Innovative and Entrepreneurial Teams (2019ZT08Y318). E.P. acknowledges funding by the Deutsche Forschungsgemeinschaft (DFG) project PL 696/4-1. S.W. acknowledges funding from the Basque Government Industry Department under the ELKARTEK and HAZITEK programs. An equal contributorship statement was added to the Acknowledgements on March 3, 2021, after initial online publication.
Publisher Copyright:
© 2020 Wiley-VCH GmbH
PY - 2021/3/3
Y1 - 2021/3/3
N2 - Bio/artificial hybrid nanosystems based on biological matter and synthetic nanoparticles (NPs) remain a holy grail of materials science. Herein, inspired by the well-defined metal–organic framework (MOF) with diverse chemical diversities, the concept of “armored red blood cells” (armored RBCs) is introduced, which are native RBCs assembled within and protected by a functional exoskeleton of interlinked MOF NPs. Exoskeletons are generated within seconds through MOF NP interlocking based on metal-phenolic coordination and RBC membrane/NP complexation via hydrogen-bonding interactions at the cellular interface. Armored RBC formation is shown to be generalizable to many classes of MOF NPs or any NPs that can be coated by MOF. Moreover, it is found that armored RBCs preserve the original properties of RBCs (such as oxygen carrier capability and good ex ovo/in vivo circulation property) and show enhanced resistance against external stressors (like osmotic pressure, detergent, toxic NPs, and freezing conditions). By modifying the physicochemical properties of MOF NPs, armored RBCs provide the capability for blood nitric oxide sensing or multimodal imaging. The synthesis of armored RBCs is straightforward, reliable, and reversible and hence, represent a new class of hybrid biomaterials with a broad range of functionalities.
AB - Bio/artificial hybrid nanosystems based on biological matter and synthetic nanoparticles (NPs) remain a holy grail of materials science. Herein, inspired by the well-defined metal–organic framework (MOF) with diverse chemical diversities, the concept of “armored red blood cells” (armored RBCs) is introduced, which are native RBCs assembled within and protected by a functional exoskeleton of interlinked MOF NPs. Exoskeletons are generated within seconds through MOF NP interlocking based on metal-phenolic coordination and RBC membrane/NP complexation via hydrogen-bonding interactions at the cellular interface. Armored RBC formation is shown to be generalizable to many classes of MOF NPs or any NPs that can be coated by MOF. Moreover, it is found that armored RBCs preserve the original properties of RBCs (such as oxygen carrier capability and good ex ovo/in vivo circulation property) and show enhanced resistance against external stressors (like osmotic pressure, detergent, toxic NPs, and freezing conditions). By modifying the physicochemical properties of MOF NPs, armored RBCs provide the capability for blood nitric oxide sensing or multimodal imaging. The synthesis of armored RBCs is straightforward, reliable, and reversible and hence, represent a new class of hybrid biomaterials with a broad range of functionalities.
KW - bioapplications
KW - biohybrid materials
KW - metal-organic frameworks
KW - multifunction
KW - red blood cells
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U2 - 10.1002/adfm.202005935
DO - 10.1002/adfm.202005935
M3 - Article
AN - SCOPUS:85096773276
VL - 31
JO - Advanced Functional Materials
JF - Advanced Functional Materials
SN - 1616-301X
IS - 10
M1 - 2005935
ER -