Modifitsiruiushchee vliianie izmeneniǐ, sviazannykh s beremennost'iu, na kantserogenez, indutsirovannyǐ 1,2-dimetilgidrazinom, u krys.

Translated title of the contribution: Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats

N. P. Napalkov, Andrei M Mikheev, G. A. Blinova

Research output: Contribution to journalArticle

Abstract

The modifying effect of pregnancy and lactation on carcinogenesis induced by single injection of 1,2-dimethylhydrazine to female rats 30 days before mating has been studied. The total incidence of malignant tumours in rats with pseudopregnancy, single pregnancy, pregnancy and lactation, repeated pregnancies was lower in comparison with virgin animals (75, 44, 68, 59 and 93%, respectively). Colon adenocarcinoma incidence in rats with single pregnancy or repeated pregnancies was lower than that in virgin rats (42, 49 and 76%, respectively). Protective effect was observed mainly in descending colon. The mesenchymal kidney tumours were not developed at all in rats with single pregnancy. In virgin animals it was 31%. The inhibition of tumour incidence in the liver (cholangioma, cholangiocellular carcinoma) was observed in rats with single pregnancy or pregnancy and lactation in comparison with virgin control (3, 5 and 24%, respectively).

Translated title of the contributionModifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats
Original languageRussian
Pages (from-to)37-40
Number of pages4
JournalEksperimentalnaa onkologia
Volume12
Issue number6
StatePublished - Dec 1 1990

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats'. Together they form a unique fingerprint.

Cite this