Modification of silicon AFM cantilever tips with an oligo(ethylene glycol) derivative for resisting proteins and maintaining a small tip size for high-resolution imaging

Chi Ming Yam; Zhongdang Xiao; Jianhua Gu; Sabine Boutet; Chengzhi Cai

doi:10.1021/ja0350435

Modification of silicon AFM cantilever tips with an oligo(ethylene glycol) derivative for resisting proteins and maintaining a small tip size for high-resolution imaging

Chi Ming Yam, Zhongdang Xiao, Jianhua Gu, Sabine Boutet, Chengzhi Cai

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

We demonstrate that silicon AFM tips can be modified by etching with 2% HF solution followed by reaction with an α,ω-oligo(ethylene glycol)alkene. Tips properly modified by this technique maintain a small tip size and effectively reduce the nonspecific interaction with fibrinogen and bovine serum albumin, resulting in greatly improved image resolution and contrast for high-coverage fibrinogen films.

Original language	English (US)
Pages (from-to)	7498-7499
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	125
Issue number	25
DOIs	https://doi.org/10.1021/ja0350435
State	Published - Jun 25 2003
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja0350435

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Modification of silicon AFM cantilever tips with an oligo(ethylene glycol) derivative for resisting proteins and maintaining a small tip size for high-resolution imaging. / Yam, Chi Ming; Xiao, Zhongdang; Gu, Jianhua et al.
In: Journal of the American Chemical Society, Vol. 125, No. 25, 25.06.2003, p. 7498-7499.

Research output: Contribution to journal › Article › peer-review

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AU - Boutet, Sabine

AU - Cai, Chengzhi

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AB - We demonstrate that silicon AFM tips can be modified by etching with 2% HF solution followed by reaction with an α,ω-oligo(ethylene glycol)alkene. Tips properly modified by this technique maintain a small tip size and effectively reduce the nonspecific interaction with fibrinogen and bovine serum albumin, resulting in greatly improved image resolution and contrast for high-coverage fibrinogen films.

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Modification of silicon AFM cantilever tips with an oligo(ethylene glycol) derivative for resisting proteins and maintaining a small tip size for high-resolution imaging

Abstract

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