Modification of silicon AFM cantilever tips with an oligo(ethylene glycol) derivative for resisting proteins and maintaining a small tip size for high-resolution imaging

Chi Ming Yam, Zhongdang Xiao, Jianhua Gu, Sabine Boutet, Chengzhi Cai

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

We demonstrate that silicon AFM tips can be modified by etching with 2% HF solution followed by reaction with an α,ω-oligo(ethylene glycol)alkene. Tips properly modified by this technique maintain a small tip size and effectively reduce the nonspecific interaction with fibrinogen and bovine serum albumin, resulting in greatly improved image resolution and contrast for high-coverage fibrinogen films.

Original languageEnglish (US)
Pages (from-to)7498-7499
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number25
DOIs
StatePublished - Jun 25 2003
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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