Modest genetic influence on bronchodilator response: A study in healthy twins

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David Laszlo Tarnoki, Emanuela Medda, Adam Domonkos Tarnoki, Andras Bikov, Zsofia Lazar, Corrado Fagnani, Maria Antonietta Stazi, Kinga Karlinger, Zsolt Garami, Viktor Berczi, Ildiko Horvath

Aim: To determine the reasons for large standard deviation of bronchodilator response (BDR) and establish whether there is a potential heritable component in healthy subjects. Methods: 67 monozygotic and 42 dizygotic adult twin pairs were assessed for bronchodilator response (% change in FEV1 after inhaling 400 μg salbutamol). Univariate quantitative genetic modeling was performed. Results: Multiple regression modeling showed a significant association between BDR and sex and baseline FEV1 (P < 0.05), while no association was found with smoking habits, body mass index, or age. Within pair correlation in monozygotic twins was modest (0.332), but higher than in dizygotic twins (0.258). Age-, sex-, and baseline FEV1- adjusted genetic effect accounted for 14.9% (95% confidence interval, CI 0%-53.1%) of the variance of BDR, shared environmental effect for 18.4% (95% CI 0%-46.8%), and unshared environmental effect for 66.8% (95% CI 46.8%-88.7%). Conclusion: Our twin study showed that individual differences in BDR can be mostly explained by unshared environmental effects. In addition, it is the first study to show low, insignificant hereditary influences, independently from sex, age, and baseline FEV1.

Original languageEnglish (US)
Pages (from-to)152-158
Number of pages7
JournalCroatian Medical Journal
Volume56
Issue number2
DOIs
StatePublished - 2015

PMID: 25891875

PMCID: PMC4410177

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Modest genetic influence on bronchodilator response : A study in healthy twins. / Tarnoki, David Laszlo; Medda, Emanuela; Tarnoki, Adam Domonkos; Bikov, Andras; Lazar, Zsofia; Fagnani, Corrado; Stazi, Maria Antonietta; Karlinger, Kinga; Garami, Zsolt; Berczi, Viktor; Horvath, Ildiko.

In: Croatian Medical Journal, Vol. 56, No. 2, 2015, p. 152-158.

Research output: Contribution to journalArticle

Harvard

Tarnoki, DL, Medda, E, Tarnoki, AD, Bikov, A, Lazar, Z, Fagnani, C, Stazi, MA, Karlinger, K, Garami, Z, Berczi, V & Horvath, I 2015, 'Modest genetic influence on bronchodilator response: A study in healthy twins' Croatian Medical Journal, vol. 56, no. 2, pp. 152-158. https://doi.org/10.3325/cmj.2015.56.152

APA

Tarnoki, D. L., Medda, E., Tarnoki, A. D., Bikov, A., Lazar, Z., Fagnani, C., ... Horvath, I. (2015). Modest genetic influence on bronchodilator response: A study in healthy twins. Croatian Medical Journal, 56(2), 152-158. https://doi.org/10.3325/cmj.2015.56.152

Vancouver

Tarnoki DL, Medda E, Tarnoki AD, Bikov A, Lazar Z, Fagnani C et al. Modest genetic influence on bronchodilator response: A study in healthy twins. Croatian Medical Journal. 2015;56(2):152-158. https://doi.org/10.3325/cmj.2015.56.152

Author

Tarnoki, David Laszlo ; Medda, Emanuela ; Tarnoki, Adam Domonkos ; Bikov, Andras ; Lazar, Zsofia ; Fagnani, Corrado ; Stazi, Maria Antonietta ; Karlinger, Kinga ; Garami, Zsolt ; Berczi, Viktor ; Horvath, Ildiko. / Modest genetic influence on bronchodilator response : A study in healthy twins. In: Croatian Medical Journal. 2015 ; Vol. 56, No. 2. pp. 152-158.

BibTeX

@article{d362ab6fda584933af1157eb221e8054,
title = "Modest genetic influence on bronchodilator response: A study in healthy twins",
abstract = "Aim: To determine the reasons for large standard deviation of bronchodilator response (BDR) and establish whether there is a potential heritable component in healthy subjects. Methods: 67 monozygotic and 42 dizygotic adult twin pairs were assessed for bronchodilator response ({\%} change in FEV1 after inhaling 400 μg salbutamol). Univariate quantitative genetic modeling was performed. Results: Multiple regression modeling showed a significant association between BDR and sex and baseline FEV1 (P < 0.05), while no association was found with smoking habits, body mass index, or age. Within pair correlation in monozygotic twins was modest (0.332), but higher than in dizygotic twins (0.258). Age-, sex-, and baseline FEV1- adjusted genetic effect accounted for 14.9{\%} (95{\%} confidence interval, CI 0{\%}-53.1{\%}) of the variance of BDR, shared environmental effect for 18.4{\%} (95{\%} CI 0{\%}-46.8{\%}), and unshared environmental effect for 66.8{\%} (95{\%} CI 46.8{\%}-88.7{\%}). Conclusion: Our twin study showed that individual differences in BDR can be mostly explained by unshared environmental effects. In addition, it is the first study to show low, insignificant hereditary influences, independently from sex, age, and baseline FEV1.",
author = "Tarnoki, {David Laszlo} and Emanuela Medda and Tarnoki, {Adam Domonkos} and Andras Bikov and Zsofia Lazar and Corrado Fagnani and Stazi, {Maria Antonietta} and Kinga Karlinger and Zsolt Garami and Viktor Berczi and Ildiko Horvath",
year = "2015",
doi = "10.3325/cmj.2015.56.152",
language = "English (US)",
volume = "56",
pages = "152--158",
journal = "Croatian Medical Journal",
issn = "0353-9504",
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number = "2",

}

RIS

TY - JOUR

T1 - Modest genetic influence on bronchodilator response

T2 - Croatian Medical Journal

AU - Tarnoki, David Laszlo

AU - Medda, Emanuela

AU - Tarnoki, Adam Domonkos

AU - Bikov, Andras

AU - Lazar, Zsofia

AU - Fagnani, Corrado

AU - Stazi, Maria Antonietta

AU - Karlinger, Kinga

AU - Garami, Zsolt

AU - Berczi, Viktor

AU - Horvath, Ildiko

PY - 2015

Y1 - 2015

N2 - Aim: To determine the reasons for large standard deviation of bronchodilator response (BDR) and establish whether there is a potential heritable component in healthy subjects. Methods: 67 monozygotic and 42 dizygotic adult twin pairs were assessed for bronchodilator response (% change in FEV1 after inhaling 400 μg salbutamol). Univariate quantitative genetic modeling was performed. Results: Multiple regression modeling showed a significant association between BDR and sex and baseline FEV1 (P < 0.05), while no association was found with smoking habits, body mass index, or age. Within pair correlation in monozygotic twins was modest (0.332), but higher than in dizygotic twins (0.258). Age-, sex-, and baseline FEV1- adjusted genetic effect accounted for 14.9% (95% confidence interval, CI 0%-53.1%) of the variance of BDR, shared environmental effect for 18.4% (95% CI 0%-46.8%), and unshared environmental effect for 66.8% (95% CI 46.8%-88.7%). Conclusion: Our twin study showed that individual differences in BDR can be mostly explained by unshared environmental effects. In addition, it is the first study to show low, insignificant hereditary influences, independently from sex, age, and baseline FEV1.

AB - Aim: To determine the reasons for large standard deviation of bronchodilator response (BDR) and establish whether there is a potential heritable component in healthy subjects. Methods: 67 monozygotic and 42 dizygotic adult twin pairs were assessed for bronchodilator response (% change in FEV1 after inhaling 400 μg salbutamol). Univariate quantitative genetic modeling was performed. Results: Multiple regression modeling showed a significant association between BDR and sex and baseline FEV1 (P < 0.05), while no association was found with smoking habits, body mass index, or age. Within pair correlation in monozygotic twins was modest (0.332), but higher than in dizygotic twins (0.258). Age-, sex-, and baseline FEV1- adjusted genetic effect accounted for 14.9% (95% confidence interval, CI 0%-53.1%) of the variance of BDR, shared environmental effect for 18.4% (95% CI 0%-46.8%), and unshared environmental effect for 66.8% (95% CI 46.8%-88.7%). Conclusion: Our twin study showed that individual differences in BDR can be mostly explained by unshared environmental effects. In addition, it is the first study to show low, insignificant hereditary influences, independently from sex, age, and baseline FEV1.

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