Mn 2+ dopant-controlled synthesis of NaYF 4:Yb/Er upconversion nanoparticles for in vivo imaging and drug delivery

Gan Tian, Zhanjun Gu, Liangjun Zhou, Wenyan Yin, Xiaoxiao Liu, Liang Yan, Shan Jin, Wenlu Ren, Gengmei Xing, Shoujian Li, Yuliang Zhao

Research output: Contribution to journalArticlepeer-review

677 Scopus citations


Pure dark red emission (650-670nm) of NaYF 4:Yb/Er upconversion nanoparticles (UCNPs) is achieved by manganese ions (Mn 2+) doping. In addition, the Mn 2+- doping can also control the crystalline phase and size of the resulting UCNPs simultaneously. Drug delivery studies suggest the promise of these UCNPs as drug carriers for intracellular drug delivery and eventually as a multifunctional nanoplatform for simultaneous diagnosis and therapy.

Original languageEnglish (US)
Pages (from-to)1226-1231
Number of pages6
JournalAdvanced Materials
Issue number9
StatePublished - Mar 2 2012


  • drug delivery
  • in vivo imaging
  • Mn -doping
  • NaYF :Yb/Er
  • single-band red upconversion emission

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Medicine(all)


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