Mn 2+ dopant-controlled synthesis of NaYF 4:Yb/Er upconversion nanoparticles for in vivo imaging and drug delivery

Gan Tian; Zhanjun Gu; Liangjun Zhou; Wenyan Yin; Xiaoxiao Liu; Liang Yan; Shan Jin; Wenlu Ren; Gengmei Xing; Shoujian Li; Yuliang Zhao

doi:10.1002/adma.201104741

Mn ²⁺ dopant-controlled synthesis of NaYF ₄:Yb/Er upconversion nanoparticles for in vivo imaging and drug delivery

Gan Tian, Zhanjun Gu, Liangjun Zhou, Wenyan Yin, Xiaoxiao Liu, Liang Yan, Shan Jin, Wenlu Ren, Gengmei Xing, Shoujian Li, Yuliang Zhao

Houston Methodist

Research output: Contribution to journal › Article › peer-review

799 Scopus citations

Abstract

Pure dark red emission (650-670nm) of NaYF ₄:Yb/Er upconversion nanoparticles (UCNPs) is achieved by manganese ions (Mn ²⁺) doping. In addition, the Mn ²⁺- doping can also control the crystalline phase and size of the resulting UCNPs simultaneously. Drug delivery studies suggest the promise of these UCNPs as drug carriers for intracellular drug delivery and eventually as a multifunctional nanoplatform for simultaneous diagnosis and therapy.

Original language	English (US)
Pages (from-to)	1226-1231
Number of pages	6
Journal	Advanced Materials
Volume	24
Issue number	9
DOIs	https://doi.org/10.1002/adma.201104741
State	Published - Mar 2 2012

Keywords

drug delivery
in vivo imaging
Mn -doping
NaYF :Yb/Er
single-band red upconversion emission

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering
Medicine(all)

Access to Document

10.1002/adma.201104741

Cite this

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title = "Mn 2+ dopant-controlled synthesis of NaYF 4:Yb/Er upconversion nanoparticles for in vivo imaging and drug delivery",

abstract = "Pure dark red emission (650-670nm) of NaYF 4:Yb/Er upconversion nanoparticles (UCNPs) is achieved by manganese ions (Mn 2+) doping. In addition, the Mn 2+- doping can also control the crystalline phase and size of the resulting UCNPs simultaneously. Drug delivery studies suggest the promise of these UCNPs as drug carriers for intracellular drug delivery and eventually as a multifunctional nanoplatform for simultaneous diagnosis and therapy.",

keywords = "drug delivery, in vivo imaging, Mn -doping, NaYF :Yb/Er, single-band red upconversion emission",

author = "Gan Tian and Zhanjun Gu and Liangjun Zhou and Wenyan Yin and Xiaoxiao Liu and Liang Yan and Shan Jin and Wenlu Ren and Gengmei Xing and Shoujian Li and Yuliang Zhao",

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T1 - Mn 2+ dopant-controlled synthesis of NaYF 4:Yb/Er upconversion nanoparticles for in vivo imaging and drug delivery

AU - Tian, Gan

AU - Gu, Zhanjun

AU - Zhou, Liangjun

AU - Yin, Wenyan

AU - Liu, Xiaoxiao

AU - Yan, Liang

AU - Jin, Shan

AU - Ren, Wenlu

AU - Xing, Gengmei

AU - Li, Shoujian

AU - Zhao, Yuliang

PY - 2012/3/2

Y1 - 2012/3/2

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AB - Pure dark red emission (650-670nm) of NaYF 4:Yb/Er upconversion nanoparticles (UCNPs) is achieved by manganese ions (Mn 2+) doping. In addition, the Mn 2+- doping can also control the crystalline phase and size of the resulting UCNPs simultaneously. Drug delivery studies suggest the promise of these UCNPs as drug carriers for intracellular drug delivery and eventually as a multifunctional nanoplatform for simultaneous diagnosis and therapy.

KW - drug delivery

KW - in vivo imaging

KW - Mn -doping

KW - NaYF :Yb/Er

KW - single-band red upconversion emission

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