MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition

D. S. Chu, D. L. Sellers, M. J. Bocek, A. E. Fischedick, P. J. Horner, S. H. Pun

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

MMP9-responsive bivalirudin-HPMA copolymers were synthesized for direct, local administration in rat spinal cord contusion injury models. Polymer-conjugated bivalirudin peptides maintained activity while demonstrating enzyme-mediated release upon MMP9 exposure and prolonged release from hyaluronic acid/methylcellulose (HAMC) hydrogels compared to free bivalirudin peptide. Localized administration of bivalirudin copolymers in vivo at the site of rat spinal cord injury decreased cellular proliferation and astrogliosis, suggesting the bivalirudin copolymer and HAMC hydrogel system are a promising therapeutic intervention for reducing immediate inflammatory responses and long term scarring. This journal is

Original languageEnglish (US)
Pages (from-to)41-45
Number of pages5
JournalBiomaterials Science
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

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