Mixed endocervical adenocarcinoma and high-grade neuroendocrine carcinoma of the cervix with ovarian metastasis of the former component: A report of 2 cases

Preetha Ramalingam, Anais Malpica, Michael T. Deavers

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Endocervical adenocarcinomas (ECAs) uncommonly metastasize to the ovary; however, when they do they sometimes closely mimic a mucinous/endometrioid ovarian primary tumor. Here, 2 cases of mixed moderately differentiated ECA and high-grade cervical neuroendocrine carcinoma in which the ECA component metastasized to the ovary have been delineated and reported. In both cases, the primary tumor and the metastatic tumor were diffusely positive for p16 and high-risk human papillomavirus. Although similar to previously reported cases of adenocarcinoma in situ and invasive ECAs with ovarian involvement, none of the cases reported to date had concurrent neuroendocrine carcinoma with metastasis of the lower-grade component. In this respect, our cases are unique. The presence of lower uterine segment involvement in both cases and high-risk human papillomavirus positivity in the primary and metastatic tumors suggest a metastatic process, perhaps through transtubal spread, rather than independent primaries.

Original languageEnglish (US)
Pages (from-to)490-496
Number of pages7
JournalInternational Journal of Gynecological Pathology
Volume31
Issue number5
DOIs
StatePublished - Sep 2012

Keywords

  • Adenocarcinoma
  • Cervix
  • High-risk human papillomavirus
  • Metastasis
  • Neuroendocrine carcinoma
  • Ovary
  • p16

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

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