Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer

Lifo Ruan; Jun Chen; Chuanchao Du; Huiru Lu; Jiayu Zhang; Xiaomeng Cai; Rui Dou; Wenchu Lin; Zhifang Chai; Guangjun Nie; Yi Hu

doi:10.1016/j.bioactmat.2021.10.045

Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer

Lifo Ruan, Jun Chen, Chuanchao Du, Huiru Lu, Jiayu Zhang, Xiaomeng Cai, Rui Dou, Wenchu Lin, Zhifang Chai, Guangjun Nie, Yi Hu

Houston Methodist

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer. To overcome the intrinsic limitations in conventional mitochondrial targeting strategies, we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin (DOX) resistance in lung cancer. Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors. As a consequence, thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice. This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance.

Original language	English (US)
Pages (from-to)	191-199
Number of pages	9
Journal	Bioactive Materials
Volume	13
DOIs	https://doi.org/10.1016/j.bioactmat.2021.10.045
State	Published - Jul 2022

Keywords

Drug delivery
Drug resistance
Mitochondrial temperature
Nanomedicines
Thermoresponsive

ASJC Scopus subject areas

Biotechnology
Biomaterials
Biomedical Engineering

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10.1016/j.bioactmat.2021.10.045

Cite this

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title = "Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer",

abstract = "Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer. To overcome the intrinsic limitations in conventional mitochondrial targeting strategies, we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin (DOX) resistance in lung cancer. Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors. As a consequence, thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice. This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance.",

keywords = "Drug delivery, Drug resistance, Mitochondrial temperature, Nanomedicines, Thermoresponsive",

author = "Lifo Ruan and Jun Chen and Chuanchao Du and Huiru Lu and Jiayu Zhang and Xiaomeng Cai and Rui Dou and Wenchu Lin and Zhifang Chai and Guangjun Nie and Yi Hu",

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year = "2022",

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doi = "10.1016/j.bioactmat.2021.10.045",

language = "English (US)",

volume = "13",

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journal = "Bioactive Materials",

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T1 - Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer

AU - Ruan, Lifo

AU - Chen, Jun

AU - Du, Chuanchao

AU - Lu, Huiru

AU - Zhang, Jiayu

AU - Cai, Xiaomeng

AU - Dou, Rui

AU - Lin, Wenchu

AU - Chai, Zhifang

AU - Nie, Guangjun

AU - Hu, Yi

PY - 2022/7

Y1 - 2022/7

N2 - Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer. To overcome the intrinsic limitations in conventional mitochondrial targeting strategies, we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin (DOX) resistance in lung cancer. Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors. As a consequence, thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice. This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance.

AB - Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer. To overcome the intrinsic limitations in conventional mitochondrial targeting strategies, we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin (DOX) resistance in lung cancer. Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors. As a consequence, thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice. This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance.

KW - Drug delivery

KW - Drug resistance

KW - Mitochondrial temperature

KW - Nanomedicines

KW - Thermoresponsive

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DO - 10.1016/j.bioactmat.2021.10.045

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SN - 2452-199X

VL - 13

SP - 191

EP - 199

JO - Bioactive Materials

JF - Bioactive Materials

ER -

Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer

Abstract

Keywords

ASJC Scopus subject areas

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